SAT-631 Hospital Outcomes in Women with Diabetes Mellitus and Polycystic Ovary Syndrome: Insights from National Inpatient Sample (2016-2020)

Abstract Disclosure: S. Alrosan: None. M. Al-Ahmad: None. B. barthel: None. Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that frequently coexists with diabetes mellitus (DM). The impact of PCOS on hospital outcomes in diabetic women is not well-defined. Using the National Inpatient Sample (NIS), this study evaluates differences in clinical outcomes and healthcare utilization in this population. Methods: This retrospective study included adult females admitted with a primary diagnosis of DM from the NIS database (2016-2020) using ICD-10 codes. Patients were divided into two groups based on the presence of a secondary diagnosis of PCOS. Key outcomes included in-hospital mortality, healthcare utilization (length of stay (LOS) total cost of care (TOC)) and in-hospital complications. Multivariable logistic regression was used to calculate adjusted odds ratios (aOR) and mean differences (aMD). Results: Among 1,347,925 women with diabetes, 5,670 (0.4%) had PCOS. Women with PCOS were significantly younger than those without PCOS (mean age 34.7 vs. 53.9 years; p<0.001). Mortality was lower in the PCOS group compared to the non-PCOS group (0.26% vs. 0.64%), and healthcare utilization trends, including length of stay (LOS) (3.84 vs. 4.72 days) and total cost of care (TOC) ($36,485 vs. $48,749), were also reduced in the PCOS group. However, these differences were not statistically significant after adjustment for demographics and comorbidities (mortality: aOR 0.65; 95% CI 0.08-5.35; p=0.692; LOS: aMD 0.017 days; 95% CI -0.21-0.25; p=0.881; TOC: aMD -$2,283; 95% CI -$5,215-$648; p=0.127). For secondary outcomes, PCOS was associated with significantly lower odds of acute kidney injury (AKI) (aOR 0.85; 95% CI 0.73-0.99; p=0.046). Other outcomes, including diabetic ketoacidosis (DKA) (aOR 0.6; 95% CI 0.34-1.06; p=0.083), hyperglycemic hyperosmolar syndrome (HHS) (aOR 0.67; 95% CI 0.21-2.08; p=0.489), myocardial infarction (aOR 0.68; 95% CI 0.25-1.86; p=0.457), cerebral infarction (aOR 0.51; 95% CI 0.07-3.4; p=0.488), sepsis (aOR 1.65; 95% CI 0.61-2.64; p=0.862), and respiratory failure (aOR 0.67; 95% CI 0.43-1.05; p=0.082), showed no significant differences between groups. Conclusion: Women with PCOS and diabetes showed no difference in mortality, reduced length of stay, or lower healthcare costs compared to those without PCOS. However, PCOS was associated with a significantly lower risk of acute kidney injury. The younger age of women with PCOS may partly explain these findings. Further research is needed to explore the underlying mechanisms and to identify targeted strategies for optimizing hospital outcomes in this population. Presentation: Saturday, July 12, 2025