MON-821 Trends And Disparities Of Hypothyroidism Associated Heart Failure Among Us Adult Population: A 20 Year CDC Wonders Analysis

Abstract Disclosure: E.U. Warraich: None. H. Safdar Ali: None. N. Noor: None. A. Aisha: None. A. Komel: None. M. Hassan: None. M. Asghar: None. Q. Bashir: None. T. Asghar: None. A. Siddiqua: None. A. Mehmood: None. A. Ullah: None. R. Haider: None. Introduction: Hypothyroidism impacts cardiovascular function, increasing heart failure risk. The purpose of this study is to examine trends in hypothyroidism-related heart failure death rates across the US from 1999 to 2020 in order to provide a current picture of the disease's consequences and identify regional differences. Methods: This descriptive study used data from the CDC WONDER database, of individuals aged 25 and older. ICD-10 codes E02 E03 and I50 were used. AAMRs per 100,000 population were calculated and stratified by gender, race, census region, and urban-rural classification. JOINTPOINT analysis was done to estimate annual percent changes (APCs) with 95% confidence intervals (CIs). Statistical significance was set at p < 0.05. Results: The annual mortality trends for hypothyroidism and heart failure (ICD codes E02, E03, I50) show a total of 91,125 deaths. Asian/Pacific Islander group had a minor, statistically insignificant decline from 2000 to 2018 (APC = -0.8561, LCI: -2.1564, UCI: 0.4616), followed by a sharp but insignificant increase. White individuals saw several periods of non-significant declines, with a notable rise in mortality from 2016 to 2020 (APC = 7.0299*, LCI: 4.7242, UCI: 9.3863). Both Hispanic/Latino and Black/African American groups experienced a decline from 1999 to 2016, followed by a substantial increase from 2016 to 2020. Urbanization patterns highlighted varying trends across metro categories, with large metro areas seeing significant declines followed by notable increases in the post-2016 period. Gender analysis shows a decline for females from 2002 to 2009 (APC = -3.7529*, LCI: -5.5352, UCI: -1.9371), followed by a significant increase from 2016 to 2020. While in men there was decline from 1999 to 2009, followed by a rise post-2016. Census region trends indicated the highest mortality rates in the Midwest (AAMR= 2.3214), followed by the West, South, and Northeast, with each region demonstrating distinct declines and increases over time. The most prominent shifts occurred between 2016 and 2020 across regions, showing increases in mortality following previous periods of decline. These findings underscore the significant temporal changes in mortality across race, urbanization, gender, and geographic regions, with especially sharp increases after 2016. Conclusion: Since 1999 to 2020, mortality from hypothyroidism related heart failure—underwent a substantial shift. Highest changes were from 2016 to 2020, especially among females, Hispanic, Black, rural populations. Thus, these trends reflect shifting systemic healthcare issues and calls for urgent public health interventions. Presentation: Monday, July 14, 2025