SAT-270 Clinical Outcomes for Patients with PCOS and Hyperlipidemia: An Analysis of the National Inpatient Sample

Abstract Disclosure: T. Elias: None. M. Singh: None. D.C. Thor: None. S. Prasad: None. Introduction: As clinicians continue to improve their recognition and management of polycystic ovarian syndrome (PCOS), it remains imperative to understand the health outcomes for these patients over time. Limited data is available on the comorbid correlations for the PCOS population. Objectives: We sought to examine the National Inpatient Sample (NIS) database to describe in-hospital outcomes among patients with PCOS and hyperlipidemia. Methods: Data were extracted from the NIS database from 2019 and 2020. The NIS was searched for hospitalizations of all patients greater than 18 years old who had PCOS. We then analyzed the outcomes of patients with hyperlipidemia. Multivariate logistic regression analysis was used to adjust for confounders. The primary outcome was inpatient mortality and secondary outcomes were annotated accordingly. SPSS software was used for statistical analysis, and all results were powered to p<0.001. Results: This study included 32,385 patients with PCOS, of which 4945 (15.3%) were identified as also having hyperlipidemia. Multivariate regression demonstrated that hyperlipidemic patients with PCOS had higher inpatient mortality (OR 1.426, CI 1.234-1.636, p<0.001). On secondary analysis, hyperlipidemic PCOS patients were more likely to have systemic lupus erythematosus (OR 1.267, CI 1.187-1.352), metabolic-dysfunction associated fatty liver disease (OR 1.458, CI 1.411-1.508), anemia (OR 1.209, CI 1.196-1.221), thrombocytopenia (OR 1.226, CI 1.188-1.265), hypertension (OR 1.993, CI 1.883-2.110), chronic kidney disease (OR 1.831, CI 1.723-1.945), acute renal failure (OR 1.514, CI 1.455-1.575), pancreatitis (OR 1.521, CI 1.412-1.639), mitral regurgitation (OR 1.333, CI 1.225-1.451), pericarditis (OR 1.288, CI 1.161-1.428), intracranial hemorrhage (OR 1.429, CI 1.225-1.665), chronic obstructive pulmonary disease (OR 1.757, CI 1.639-1.882), severe liver disease (OR 1.401, CI 1.322-1.485), metastatic cancers (OR 1.369, CI 1.293-1.449), all-cause arrhythmias (OR 1.347, CI 1.293-1.402), all-cause shock (OR 1.464, CI 1.298-1.652), all-cause heart block (OR 1.612, CI 1.427-1.821), all-cause sepsis (OR 1.279, CI 1.254-1.304), all-cause coagulopathy (OR 1234, CI 1.197-1.272), all-cause heart failure (OR 1.851, CI 1.739-1.969), all-cause stroke (OR 1.502, CI 1.430-1.577), and all-cause myocardial infarction (OR 2.451, CI 2.177-2.759). Conclusion: In this nationally-representative, population-based retrospective cohort study, hospitalized patients with PCOS and hyperlipidemia were associated with higher mortality and worse outcomes. Further analysis and/or discussion is necessary to improve the care of this potentially underserved population. Presentation: Saturday, July 12, 2025