SAT-257 Descriptive Analysis Of Lipoprotein A, And Associated Variables In A Colombian Northeastern Reference Laboratory

Abstract Disclosure: G.A. Parra Serrano: None. L. Neira Fuentes: None. A. Reyes Gonzalez: None. P. Mantilla Mantilla: None. M. Buitrago Gomez: None. D. Capacho Quintana: None. Introduction: Cardiovascular disease is the leading cause of death worldwide. Lipoprotein (a) [Lp(a)] has been recognized as an independent marker associated with cardiovascular events. Objective: Descriptively analyze Lp(a) behavior in Santander, Colombia, reference laboratory. Methodology: 603 persons, samples, anonymized database, ethical committee approval.Included variables: Age, Gender, Fasting glucose, creatinine, total cholesterol, tryglicerydes, HDL, LDL, ApoB, and lipoprotein A in mg/dl (measured by Immuneturbimetric assay). descriptive and univariable analysis, Lp(a) percentile calculation in mg/dL and in nmol (Lp(a) mg/dL x 2.15), bivariate analysis, pearson correlation test, for association between Lp(a) and age, sex, fasting glucose, creatinine and lipid profile, ApoB. Results: The average age was 58 +- 14.4 years, 57% women, median Lp(a) was (14.1 mg/dL or 30.31 nmol/L) (IQR 5.2 to 52.2 mg/dL), fasting glucose 97.5 (IC95% 22mg/dl), Creatinine 0.97mg/dl (IC95% 0.28), Lp(a) divided by deciles in (mg/dl - nmol/L), decil 10 (3mg/dl - 6.45 nmol/L), decil 20 (4.48mg/dl - 9.6nmol/L), decil 30 (6.4 mg/dl - 13.7 nmol/L), decil 40 (8.96mg/dl - 19.2 nmol/L), decil 50 14.1mg/dl - 30.3 nmol/L), decil 60 (23mg/dl - 50.095 nmol/L), decil 70 39.4 mg/dl - 84nmo/L), decil 80 (64.7mg/dl - 139.1 nmol/L), decil 90 (103.4 mg/dl - 222 nmol/L) , decil 99 (199mg/dl - 429 nmol/L).Simple linear regression analysis and T-test were performed to observe association of independent variables and Lp(a). No-association observed.There were no significant differences in Lipoprotein (a) values ​​according to gender (male and female). Also, No significant differences observed after 2 measures of lp(a) in the same person. After dichotomization of Lp(a) <50mg/dl or >50mg/dl, no association was found in any variable. No association in lp(a) value after Dichotomization by fasting glucose <126mgdl and >126mg/dl and women’s age <50 and >50 years . Conclusions: Median Lp(A) in our population was 14.1mg/dl (30.3nmol/l). No-significant statistical associations was found between Lp(a) value ​​and variables studied. after dichotomization of fasting glucose in diabetes range and age by menopauseal status, no difference was found in lp (a) value.Non - normal distribution is similar than observed in other studies. Keywords: Lipoprotein A, Lp(a), Cardiovascular risk, Risk factors, Clinical parameters Presentation: Saturday, July 12, 2025