MON-418 Geographic, Gender, and Racial Disparities in Myxedema Coma-Related Mortality in the United States (1999-2020)

Abstract Disclosure: E. Assaf: None. A. Musallam: None. H. Munshi: None. A. Shubietah: None. G. Makhoul: None. A. Albadawi: None. A. Hammad: None. I. Rajab: None. A. Ahmad: None. Background: Myxedema coma is a rare but life-threatening complication of severe hypothyroidism, often associated with significant mortality. Understanding the geographic, gender, and racial trends in myxedema coma-related mortality is crucial for identifying high-risk populations and guiding preventive strategies. Methods: A retrospective analysis of myxedema coma-related deaths from 1999 to 2020 was conducted using CDC WONDER data. Crude and age-adjusted mortality rates (AAMR) per 100,000 population were analyzed, stratified by state, year, gender, and race. Geographic and demographic patterns were examined to assess variations in mortality trends. Results: A total of 1,238 myxedema coma-related deaths were identified. Geographic analysis revealed that California had the highest mortality with 122 deaths, while the District of Columbia had the lowest mortality with 10 deaths. Gender analysis demonstrated that females had higher mortality (300 deaths) compared to males (150 deaths), reflecting the higher prevalence of hypothyroidism among women. Racial disparities were also notable, with White individuals experiencing the highest mortality (280 deaths), followed by Black or African American (120 deaths), Hispanic (50 deaths), and Asian or Pacific Islander (30 deaths). Temporal trends demonstrated fluctuating mortality rates over the years, with notable variation in urban versus rural populations. Large central metro areas reported the highest mortality counts, indicating potential disparities in access to timely diagnosis and intervention. Conclusion: Myxedema coma-related mortality remains a critical concern, particularly in specific geographic regions and urban centers. Disparities based on gender and race highlight the need for targeted public health interventions. Increased awareness, early detection, and improved healthcare access are essential to reducing the burden of this condition. Keywords: Myxedema coma, hypothyroidism, mortality, epidemiology, CDC WONDER, geographic disparities, gender disparities, racial disparities, temporal trends Presentation: Monday, July 14, 2025