MON-393 A Registry of Thyroid Nodules in 212 Hispanic Americans from an urban area

Abstract Disclosure: R.G. Dsouza: None. J. Lee: None. E.P. Liao: None. A. Sanchez: None. K. Ziskovich: None. T. Leung: None. K. Daniel: None. L. Poretsky: None. J.E. Sanchez: None. Objective: The goal of this study is to determine the characteristics and natural history of benign thyroid nodules (TN) in Hispanic Americans living in an urban area. Methods: We examined 212 Hispanic Americans, (January 2024 - January 2025). Participants were aged 18+, self-identified as LatinX, and with diagnosed TN. A chart review was conducted for demographic, medical, and thyroid function data. LUMP score, cosmetic score, and ThyPRO symptom score were assessed. As part of a long-term prospective registry, statistical analyses using descriptive statistics, linear/ordinal regression models, Kruskal-Wallis and Fisher's tests, with a significance level of p < 0.01 were performed. Results: The median age was 59 years, a median BMI of 29 kg/m2. Participants were 92% female. Common comorbidities included diabetes (30%), hypertension (30%), and hyperlipidemia (27%). Other conditions included asthma (5%), chronic obstructive pulmonary disease (0.5%), cancer (1%), coronary artery disease (5%), and thyroid disease (17%). 15% of nodules were left-sided, 18% right-sided, and 60% were bilateral. The median number of nodules per patient was 3, with a median total nodule volume of 1.52 cm3. 74% of patients were referred due to imaging findings, followed by other reasons (19%), abnormal lab tests (4%), and symptomatic presentations (1%). The majority (98%) reported no symptoms. 1% reported one symptom, 0.5% reported three symptoms. There was a significant association between total nodule volume and cosmetic score (p=0.0007). Age was associated with both total nodule volume (p=0.0045) and the total number of nodules (p<0.0001), with older patients exhibiting larger nodule volumes and a higher number of nodules. Among 26 patients with total nodule volume measurements at baseline and 6 months, the median change in volume was -0.02 cm3. Of these, 58% showed a decrease, while 30% experienced an increase in nodule volume. After adjusting for age, no significant change in total nodule volume over time was observed. No significant changes were found in LUMP score, cosmetic score, or ThyPRO score. Age was significantly associated with the change in total nodule volume (p=0.0058), with a 3% increase in nodule volume for every year of age. No significant associations were observed between BMI, diabetes, hypertension, or hyperlipidemia and changes in total nodule volume. Conclusion: In conclusion, this study found that age was significantly associated with an increase in total nodule volume. No significant associations were observed between volume change and factors such as BMI, diabetes, hypertension, or hyperlipidemia over a 6-month timeframe. Additionally, there were no significant changes in LUMP score, cosmetic score, or ThyPRO score. Active recruitment for the registry is ongoing and we will continue to evaluate for changes every 6 months. Presentation: Monday, July 14, 2025