SUN-538 Association of Gestational Diabetes Mellitus with Metabolic Markers and Cardiovascular Risk Factors: A Meta-Analysis

Abstract Disclosure: M. Tham: None. L.S. Law: None. R. Tan: None. V. Ramadoss: None. B. Tan: None. C. Sia: None. C. Khoo: None. P. Eng: None. Introduction: Women with gestational diabetes mellitus (GDM) are at increased risk of cardiovascular disease (CVD). However, mechanisms linking GDM to CVD remain unclear and CVD could occur in women with GDM independent of subsequent development of Type 2 Diabetes Mellitus (T2DM). Metabolic disturbances in women with GDM may increase susceptibility to lipid accumulation and subclinical atherosclerosis. In this meta-analysis, we aim to examine the association of metabolic markers such as adiponectin, and lipid profiles with GDM. Methods: Eligible cohort and observational studies were identified through PubMed, Scopus, EMBASE, and The Cochrane Library, from inception to November 1, 2023. Studies evaluating the relationship between GDM, lipid profiles, and cardiovascular markers were included. Data were extracted independently by two reviewers. Overall effect estimates were reported as standardized mean differences (SMD) with 95% confidence intervals (CIs). Results: Out of 5,030 studies screened, 227 met the inclusion criteria, comprising a total of 1,267,064 participants. Women with a history of GDM had higher levels of total cholesterol (SMD 0.51; 95% CI 0.15, 0.87; n = 197), low density lipoprotein cholesterol (SMD 0.55; 95% CI 0.13, 0.97; n = 181), and triglycerides (SMD 1.24; 95% CI 0.63, 1.84; n = 227) but lower levels of high density lipoprotein cholesterol (SMD -0.84; 95% CI -1.36, -0.31; n = 206) and adiponectin (SMD -0.88; 95% CI -1.25, -0.52; n = 50). There was no significant difference in HOMA-IR (SMD 1.01; 95% CI 0.81, 1.20; n = 186). Conclusion: Women with a history of GDM exhibited dyslipidemia and lower adiponectin levels compared to women without GDM. These findings suggest an early perturbation in metabolism in women diagnosed with GDM without changes in insulin resistance. Studies on lifestyle intervention targeting dyslipidemia and low adiponectin among women with GDM are needed. Presentation: Sunday, July 13, 2025