SAT-567 Global Trends in the Prevalence and Incidence of Chronic Kidney Disease Due to Type 1 Diabetes Among Adults Aged 55 and Older (1990-2021): A Global Burden Of Disease Study

Abstract Disclosure: G. Flocco: None. A. Cheema: None. M. Munir: None. F. Ahmed: None. A. Zahid: None. H. Ahmad: None. M. Kakakhel: None. M. Ali: None. J. Ikram: None. Chronic kidney disease (CKD) is a major complication of type 1 diabetes (T1D), with its burden rising globally due to aging populations. Despite advancements in diabetes care, the trends in CKD prevalence and incidence among older adults with T1D remain poorly understood. This study leverages Global Burden of Disease (GBD) data to provide novel insights into the evolving impact of CKD attributable to T1D in adults aged 55 and older from 1990 to 2021. We utilized data from the Global Burden of Disease (GBD) study to examine temporal trends in the incidence and prevalence of CKD attributable to T1DM between 1990 and 2021. To evaluate these trends, we calculated the Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC) with corresponding 95% confidence intervals (CI), determining statistical significance through p-values. Over the past three decades, the global burden of CKD attributable to T1DM has risen dramatically. In 1990, the global incidence of CKD linked to T1DM was 4,503.14 per 100,000, which surged to 14,729.89 per 100,000 by 2021. Similarly, the global prevalence increased significantly from 401,004.7 per 100,000 in 1990 to 1,087,675 per 100,000 in 2021. The AAPC analysis demonstrated a significant upward trend in both global incidence (AAPC: 1.2908, 95% CI: 1.2599-1.3178, p < 0.000001) and prevalence (AAPC: 0.6397, 95% CI: 0.6125-0.6668, p < 0.000001). The APC analysis revealed several remarkable trends. The global incidence of CKD due to T1DM experienced its most significant surge between 1995 and 2004 (APC: 2.7010, 95% CI: 2.6106-2.7884, p = 0.006399), while the slowest increase occurred from 2019 to 2021 (APC: 0.6099, 95% CI: 0.0217-1.0093, p = 0.044391). In contrast, the prevalence of CKD due to T1DM saw its sharpest growth during 1996-1999 (APC: 2.9191, 95% CI: 2.549-3.176, p < 0.000001), with the most gradual rise recorded between 2005 and 2010 (APC: 0.8331, 95% CI: 0.468-1.018, p < 0.000001). The global burden of CKD attributable to T1DM has increased dramatically over the past three decades, with incidence and prevalence exhibiting significant upward trends. These findings underscore the urgent need for targeted interventions and global strategies to address the growing impact of CKD in individuals with T1DM, particularly among aging populations. Presentation: Saturday, July 12, 2025