SAT-566 Regional Trends in Mortality and Disability-Adjusted Life Years (DALYs) of Chronic Kidney Disease Due to Type 1 Diabetes Among Adults Aged 55 and Older (1990-2021): A Global Burden Of Disease Study

Abstract Disclosure: G. Flocco: None. M. Munir: None. H. Ahmad: None. M. Kakakhel: None. M. Ali: None. F. Ahmed: None. J. Ikram: None. A. Zahid: None. A. Cheema: None. Chronic kidney disease (CKD) due to type 1 diabetes mellitus (T1DM) poses a growing health challenge, especially among older adults. This study explores regional variations in DALYs, and mortality trends associated with CKD due to T1DM over the past three decades (1990-2021). We examined data from the Global Burden of Disease (GBD) study over a period of three decades (1990-2021) to evaluate the trends in DALYs and mortality rates associated with CKD due to T1DM among adults aged 55 and older. The data were stratified by region and income level, utilizing the Socio-demographic Index (SDI). Changes in DALYs and deaths were assessed using the Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC), with corresponding 95% confidence intervals (CI). Over the study period, CKD due to T1DM accounted for a total of 1.82 million deaths and 52.13 million DALYs across all regions. In 1990, the highest burden of DALYs was observed in the Middle SDI region, followed by East Asia and Low-Middle SDI regions. Notably, these regions also recorded the highest number of deaths in the same year. By 2021, the Middle SDI region continued to have the highest numbers of DALYs and deaths, followed by the Low-Middle SDI region and East Asia. In 2021, the highest DALY rates per 100,000 were observed in Oceania, which replaced Eastern Sub-Saharan Africa as the region with the highest rates in 1990. Oceania was followed by Andean Latin America and Central Latin America. Similarly, the highest mortality rates in 2021 were recorded in the same regions. In 2021, the lowest DALY and mortality rates were observed in Australasia, Western Europe, Central Europe, and Central Asia, reflecting a comparatively lower burden of CKD due to T1DM in these regions. Based on the AAPC analysis, the highest DALYs were recorded in High-Income North America (AAPC: 3.23; 95% CI: 3.15-3.31; p < 0.000001), followed by Central Latin America (AAPC: 2.13; 95% CI: 1.82-2.32; p < 0.000001) and Central Asia (AAPC: 2.08; 95% CI: 1.90-2.24, p < 0.000001). Similarly, the highest mortality rates were observed in High-Income North America (AAPC: 3.79; 95% CI: 3.69-3.88; p < 0.000001), followed by Central Asia (AAPC: 2.81; 95% CI: 2.57-3.04; p < 0.000001) and Central Latin America (AAPC: 2.02; 95% CI: 1.82-2.21; p < 0.000001). Over the study period, CKD due to T1DM demonstrated a significant and growing burden, with notable regional variations in DALYs and mortality. Our analysis highlights the alarming rise in high-income and middle-income regions, underscoring the need for targeted interventions to address this escalating global health challenge. Presentation: Saturday, July 12, 2025