SUN-137 Can partial empty sella and empty sella manifest with visual field defects?

Abstract Disclosure: B. Kałuża: None. M. Furmanek: None. P. Siwik: None. N. Bujnowska: None. J. Domański: None. A. Żuk-Łapan: None. E. Filipiak: None. J. Walecki: None. E. Franek: None. Background Primary empty sella and partial empty sella are described as a herniation of the subarachnoid space into the sella turcica as a result of idiopathic intracranial hypertension, or other causes. The resulting compression and flattening of the pituitary gland may be asymptomatic or manifest with certain visual symptoms. The aim of this study was to assess the visual fields of patients with primary partial empty sella or empty sella. Material and methods Out of 594 patients who had undergone pituitary magnetic resonance imaging (MRI), 43 patients diagnosed with partial empty sella or empty sella were selected to undergo a prospective examination of both of their eyes (86eyes). Moreover, the patients underwent pituitary and optic nerve MRI and hormone tests. Visual fields were assessed with a full-field 120-point screening test, and visual field defects were expressed as proportions of the entire visual field and of individual quadrants (superior temporal, inferior temporal, superior nasal, and inferior nasal). The evaluated eyes were divided into two groups: Group 1: the eyes of patients with partial empty sella and the pituitary measuring > 2 mm craniocaudally (n=68), Group 2: the eyes of patients with empty sella and the pituitary measuring ≤ 2 mm craniocaudally (n=18). Results Patients from the study groups did not differ in terms of the extent of visual field defects (%) either in the entire visual field (5.404±9.731 vs. 2.685±3.472, p=0.937) or in the superior nasal (5.465±10.722 vs.2.160 ±3.635, p=0.647), superior temporal (7.219±14.526 vs. 3.788 ± 6.660, p=0.962), inferior nasal (5.53±12.736 vs. 2.303±2.837, p=0.764) or inferior temporal (3.377±8.765 vs. 3.387±5.395, p=0.319) quadrant. Logistic regression analysis showed none of the following parameters: the pituitary craniocaudal diameter (OR 5.823; 95%CI (0.287-118.157), p=0.251), pituitary volume (OR 0.992; 95%CI [0.980-1.004], p=0.186), craniocaudal sellar dimension (OR 0.844; 95%CI [0.402-1.773], p=0.654), sellar volume (OR 1.000; 95%CI [0.997-1.003], p=0.935), or pituitary volume expressed as a percentage of sellar volume (OR 0.854; 95%CI (0.686-1.064), p=0.16) to be significant independent risk factors for defects in the entire visual field. Conclusion Neither the volume nor craniocaudal diameter of the pituitary is a risk factor for visual field defects in patients with partial empty sella or empty sella. Nonetheless, these patients should undergo ophthalmologic examinations. Presentation: Sunday, July 13, 2025