SAT-596 Global Trends in the Mortality and Disability Adjusted Life Years (DALYs) of Chronic Kidney Disease Due to Type 1 Diabetes Among Adults Aged 55 and Older (1990-2021): A Global Burden Of Disease Study

Abstract Disclosure: S. Khan: None. H. Ahmad: None. M. Kakakhel: None. M. Ali: None. F. Ahmed: None. H. Ilyas: None. I. Ahmad: None. M. Haider: None. Background: Effective health system planning requires a detailed understanding of the epidemiology of chronic kidney disease (CKD) attributable to type 1 diabetes mellitus (T1DM). However, data on the morbidity and mortality of this condition remain scarce. Disability-adjusted life years (DALYs) are widely used to quantify the burden of disease in terms of morbidity, while mortality rates are calculated separately to measure the frequency of deaths. In this analysis of the Global Burden of Disease Study 2021, we aimed to characterize global trends in DALYs and mortality rates associated with CKD due to T1DM over the 30-year period from 1990 to 2021. Methods: Using data from the Global Burden of Disease (GBD) Study, we analyzed long-term trends in DALYs and mortality rates associated with CKD due to T1DM from 1990 to 2021. The Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC) with 95% confidence intervals (CI) were used to quantify these trends, with statistical significance assessed using p-values. Results: The global burden of CKD attributable to T1DM has significantly increased from 1990 to 2021. Over this 30-year period, CKD due to T1DM resulted in 26.7 million DALYs, peaking in 2021 with 1.28 million DALYs. In terms of mortality, CKD due to T1DM accounted for 16,950 deaths in 1990, which increased 2.6 times by 2021, reaching 42,875 deaths, contributing to a total of 870,700 deaths over the three decades. Overall, CKD due to T1DM caused a higher burden of morbidity compared to mortality. The AAPC analysis demonstrated a significant rise in both DALYs (AAPC: 0.4103, 95% CI: 0.3916-0.4306, p < 0.000001) and mortality rates (AAPC: 0.4472, 95% CI: 0.4247-0.4642, p < 0.000001) associated with CKD due to T1DM from 1990 to 2021. Following the APC analysis, several notable trends emerged. The most significant increase in DALYs occurred between 1996 and 2004 (APC: 1.0240, 95% CI: 0.9336-1.1542, p < 0.000001), while the slowest rise in DALYs was observed from 2007 to 2021 (APC: 0.4580, 95% CI: 0.4208-0.5081, p < 0.000001). In contrast, mortality rates increased most sharply from 1997 to 2000 (APC: 1.5067, 95% CI: 1.0084-1.6929, p = 0.010398), while the slowest increase in mortality rates occurred from 1990 to 1997 (APC: 0.2798, 95% CI: 0.1254-0.3182, p = 0.011998). Conclusion: The global burden of CKD attributable to T1DM has risen substantially over the past three decades, with notable increases in both DALYs and mortality rates. Despite a slowing trend in recent years, the overall burden of morbidity continues to outpace mortality, highlighting the need for enhanced global health strategies to address this growing concern. Presentation: Saturday, July 12, 2025