SAT-595 Gender Specific Trends in the Incidence and Prevalence of Chronic Kidney Disease Due to Type 1 Diabetes Among Adults Aged 55 and Older (1990-2021): A Global Burden Of Disease Study

Abstract Disclosure: S. Khan: None. H. Ahmad: None. M. Kakakhel: None. M. Ali: None. F. Ahmed: None. H. Ilyas: None. I. Ahmad: None. M. Haider: None. Background: Chronic kidney disease (CKD) due to type 1 diabetes mellitus (T1DM) poses a growing global public health challenge. However, comprehensive global assessments of the burden of CKD due to T1DM remains limited. This study examines gender-specific trends in the incidence and prevalence of CKD related to T1DM in adults aged 55 and older from 1990 to 2021, using data from the Global Burden of Disease (GBD) study to provide a clearer understanding of this evolving health issue. Methods: We analyzed data from the GBD study to investigate gender-specific trends in the incidence and prevalence of CKD due to T1DM from 1990 to 2021. Temporal changes were assessed using the Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC), accompanied by their 95% confidence intervals (CI), with statistical significance determined through p-values. Results: Throughout the study period, both the incidence and prevalence of CKD attributable to T1DM have experienced substantial increases. In 1990, the incidence was 2,747.79 cases in men, compared to 1,755.34 cases in women. By 2021, the incidence in men had nearly quintupled, reaching 9,236.96 cases, while in women it increased to 5,492.91 cases. Regarding prevalence, in 1990, the number of cases in women was 214,917, rising to 584,344.5 by 2021. For men, prevalence was 186,087 in 1990, escalating to 503,330.7 by 2021. While women exhibited a higher overall prevalence, men demonstrated a greater burden of new cases. The AAPC analysis revealed that the incidence of CKD due to T1DM increased more significantly in men (AAPC: 1.32, 95% CI: 1.28-1.34, p < 0.000001) compared to women (AAPC: 1.18, 95% CI: 1.15-1.205, p < 0.000001). In contrast, prevalence was higher in women (AAPC: 0.71, 95% CI: 0.68-0.73, p < 0.000001) than in men (AAPC: 0.60, 95% CI: 0.56-0.63, p < 0.000001). Following the APC analysis, several notable trends emerged. The most significant increase in male incidence occurred between 2010-2015 (APC: 3.07, 95% CI: 2.93-3.23), while for females, the greatest increase was observed between 1996-1999 (APC: 3.73, 95% CI: 3.41-3.97). In contrast, male prevalence peaked during 2010-2015 (APC: 2.07, 95% CI: 1.91-2.31), while female prevalence saw the sharpest rise from 1996-1999 (APC: 3.37, 95% CI: 3.07-3.56). Conclusion: The incidence and prevalence of CKD attributable to T1DM have significantly increased over the past three decades, with men showing a greater rise in incidence and women exhibiting higher overall prevalence. These findings underscore the growing global burden of CKD due to T1DM, highlighting the need for targeted public health interventions Presentation: Saturday, July 12, 2025