SUN-701 Mortality From Obesity with Cerebrovascular Diseases: A 21-year Analysis of Trends and Disparities

Abstract Disclosure: R. Ali: None. M. Zulqarnain: None. S. Yasmin: None. R. Noor: None. S. Cheema: None. H. Ijaz: None. S. Iftikhar: None. A. Dixit: None. S. Sahu: None. Background: Obesity incidence in the US has been increasing alarmingly. Obesity is linked to many cerebrovascular diseases such as stroke. There are also reports of decreased cerebral flow in obese patients which also causes exacerbation of cerebrovascular diseases. In this study, we aim to analyze the mortality rates of obesity with cerebrovascular diseases as well as the trends and demographic disparities. Methods: We analyzed death certificates from the CDC WONDER database of patients 25 years old or older that reported both obesity and cerebrovascular diseases on their death certificates, spanning more than two decades from 1999 to 2020. Data were stratified by age, gender, race, urbanization and census region. Crude Mortality Rates (CMR) and Age Adjusted Mortality Rates (AAMR) per 1000,000 people were assessed with corresponding 95% confidence intervals (CIs). Results were reported as Annual Percentage Changes (APC) and Average Annual Percent Changes (AAPC). Results: During 1999-2020, 26410 people lost their lives due to obesity with cerebrovascular diseases. The AAMR increased slowly from 3.39 in 1999 to 7.36 in 2018 (APC: 3.78; 95%CI, 2.89 to 4.55, p < 0.000001). The AAMR then rose sharply to 11.29 in just 2 years till 2020 (APC: 24.99; 95%CI, 12.53 to 31.47, p < 0.000001). Several geographic and demographic disparities were found. Females had a slightly higher AAMR than males (5.62 vs 5.16), however, males had a significantly higher increase in AAMR with AAPC of 6.86 (95%CI, 5.72 to 7.69) compared to females with AAPC of 4.86 (95%CI, 4.13 to 5.45). Upon racial stratification, Non-Hispanic (NH) Black or African Americans had the highest AAMR at 10.79 followed by the NH White population at 5.06 and the Hispanic population at 4.56. However, the NH White population had higher increase in AAMR from 1999 to 2020 with an AAPC of 5.72 (95%CI, 5.07 to 6.25) compared to NH Black population with an AAPC of 4.94 (95%CI, 3.56 to 6.04). The West region had the highest AAMR (6.14), followed by the South (5.86), the Midwest (5.83) and the Northeast (3.86). Geographically, non-metropolitan areas had a much higher AAMR (7.26) compared to metropolitan areas (5.16). The highest CMR was seen in the 75-84 year age group at 18.17 with AAPC of 5.88 (95%CI, 4.46 to 6.88) followed by 85+ year age group (16.92). The state of Vermont had the highest AAMR at 11.95. Conclusion: The mortality due to obesity with cerebrovascular diseases has been rising steadily from 1999 to 2018 and has rapidly increased from 2018 to 2020. This rise in mortality is concerning and should be investigated. Mortality rates in the Black population, females, non-metropolitan areas and the West region were disproportionately high. Specific measures directed at reducing the mortality rate in these groups are needed to reduce these disparities. Presentation: Sunday, July 13, 2025