SUN-702 When Hyperlipidemia Meets Obesity: A Retrospective Analysis of Mortality Trends and Disparities (1999-2020)

Abstract Disclosure: S. Yasmin: None. R. Ali: None. M. Zulqarnain: None. R. Noor: None. S. Cheema: None. S. Sahu: None. A. Dixit: None. S. Abdul Rehman Shah: None. S. Iftikhar: None. Introduction: The last several decades have seen an unprecedented increase in the incidence of obesity, affecting 40% of women and 35% of men in the United States (US). Considering 60-70% of obese patients have associated hyperlipidemia, both disorders entail a substantial healthcare burden. We aimed to determine trends and disparities of mortality rates of hyperlipidemia and obesity in the US from 1999-2020. Methods: We analyzed mortality trends for obesity and hyperlipidemia among adults aged 25+ using CDC WONDER data. Mortality rates were stratified by sex, region, race/ethnicity, states, place of death, and urbanization. We calculated crude mortality rates (CMR), age-adjusted mortality rates (AAMR), annual percent change (APC), and average annual percent change (AAPC), with statistical significance at p<0.05. Results: Obesity and hyperlipidemia accounted for 54089 fatalities throughout the study period. There was a significant sharp rise in the AAMR from 0.27 in 1999 to 0.59 in 2003 (APC: 22.04), followed by a significant steady rise to 1.39 in 2014 (APC: 8.53). From 2014 to 2018, the AAMR plateaued with a modest increase to 1.60 (APC: 1.83). Ultimately a significantly escalating upsurge was observed from 1.60 in 2018 to 2.48 in 2020 (APC:25.71) (AAPC: 11.19, 95% CI: 10.56 to 12.43, p<0.000001). This trend was similar across genders. Males (1.43) had higher AAMR than females (0.84), with a more pronounced increase in mortality rates after 2018, and an APC of 25.25. Overall, the age group 65-74 years revealed the highest CMR (3.08), followed by 75-84 years (2.85). Surprisingly, from 2018-2020, the age group 75-84 showed the highest mortality rates, with an APC of 26.07. When stratified by census regions, the Midwest region had the highest AAMR (1.28), followed by West (1.3), South (1.01), and Northeast (0.89). After 2018, the rise was observed across all regions but was particularly pronounced in the Northeast (APC:30.92). When stratified by race, Non-Hispanic (NH) American Indian had the highest AAMR (1.49), followed by NH Black (1.36), NH White (1.16), Hispanics (0.80) and lastly NH Asian (0.32). NH Black showed the steepest increase after 2018 (APC:32.37). Rural areas had higher AAMR (1.33) than urban (1.08), with a more pronounced rise in mortality observed in urban (AAPC: 11.14). The state of North Dakota had the highest AAMR of 2.82. Majority of deaths occurred at Decedent’s home (46.87%) Conclusion: Mortality has risen significantly over the past two decades, with a sharp surge after 2018. The disproportionately higher mortality rates among males, NH Blacks, the Northeast region, and urban areas underscore the need for targeted public health interventions. Further research is necessary to explore contributing factors and reduce mortality in these high-risk groups. Presentation: Sunday, July 13, 2025