Evaluating the therapeutic potential of a novel bacteriophage cocktail against carbapenem-resistant Pseudomonas aeruginosa in a murine burn wound infection model
Compared to the untreated control group, phage therapy significantly reduced CRP levels and bacterial loads, enhanced wound healing, and improved survival rates without any toxicity. These results demonstrate that the formulated phage cocktail is a promising alternative treatment with a protocol adaptable for on-demand clinical use.
Authors
- Oğuz Kul (ORCID: https://orcid.org/0000-0002-1282-650X)
- Ahmet Başustaoğlu (ORCID: https://orcid.org/0000-0002-2571-0637)
- Aylin Üsküdar Güçlü (ORCID: https://orcid.org/0000-0002-1872-028X)
- Ayşe Arzu Yiğit (ORCID: https://orcid.org/0000-0001-5837-6877)
- Ilgın Ata Vural (ORCID: https://orcid.org/0000-0001-6608-7397)
Institutions
- Başkent University (TR)
- Kırıkkale University (TR)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s12866-025-04435-0
- Citations
- 2
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- Baskent Üniversitesi