MON-199 Metabolic Health Differences across the Menopausal Spectrum

Abstract Disclosure: B. Nguyen: None. M. Godar: None. B. Lohse: None. B. Lisa: None. E. Ruder: None. J. Nicklas: Eli Lilly & Company, Novo Nordisk. P. Chilamkuri: None. M. Pratt: None. J. Berkley-Patton: None. L.H. Powell: None. B.M. Drees: Abbott Laboratories. Title: Metabolic Health Differences across the Menopausal Spectrum. Objectives: This study examined age-related metabolic differences in women (n=718) at risk of metabolic syndrome (MetS) across three menopausal stages: premenopausal (PreM, <45 years), menopausal transition (MenT, 45–55 years), and postmenopausal (PostM, >55 years). Methods: Demographic, anthropometric, dietary, tobacco, alcohol, recreational drug use, physical activity and bioclinical data were analyzed using Chi square tests (for categorical variables) and ANOVA tests for significant differences in group means among the age-based menopausal stages. Results: PreM group reported consuming fewer fruit and vegetable (p =0.03), had the highest perceived stress scores (p < 0.001), largest waist circumference (WC), and highest BMI. However, they had lowest levels of fasting glucose, HbA1c, and HDL cholesterol (p < 0.05) and were more likely to use tobacco and recreational drugs regularly (p < 0.05). In the MenT group, women reported less likely to use triglyceride medication (p = 0.012). They had significantly lower BMI and higher HDL cholesterol levels compared to the PreM group (p < 0.001), as well as having highest diastolic blood pressure (BP) among the three groups (p =0.036). The PostM group had the lowest perceived stress score (p<0.001), physical activity levels (p = 0.046), and BMI (p<0.001). However, they had the highest systolic BP, HbA1c levels, and HDL cholesterol (p < 0.05) and were more likely to use lipid and BP medications (p < 0.05). Across the menopausal stages, differences in relationship between metabolic outcomes and lifestyle factors were noticed. In the PreM group, BP was positively associated with tobacco use, glucose and HbA1c levels were negatively linked to alcohol, and recreational drug use and HDL cholesterol showed a negative relationship with perceived stress. Among the MenT group, physical activity was negatively associated with WC, while glucose levels were positively linked to both alcohol and recreational drug use. For individuals in the PostM group, triglyceride levels showed a positive association with tobacco use, while alcohol use was negatively associated with HbA1c and positively linked with elevated HDL cholesterol. Conclusions: These findings highlight the importance of tailoring interventions addressing lifestyle behaviors and metabolic health in women across the menopausal spectrum. Future research could explore mechanisms to explain the differences and the benefits of early intervention for long-term health outcomes. Presentation: Monday, July 14, 2025