Monoterpenoids from the Roots of Liquidambar formosana (Formosan Sweet Gum) Exhibit Senomorphic Activity Against Cellular Senescence
These results suggest that cinnamic acid-conjugated monoterpenoids may serve as interesting lead structures for the development of agents targeting the p16<sup>INK4A</sup> pathway for the treatment of aging-associated diseases. Further studies will be required to clarify the mechanisms of action of this compound and to evaluate its in vivo efficacy.
Authors
- Van-Hieu Mai (ORCID: https://orcid.org/0000-0002-5077-2899)
- Won Keun Oh (ORCID: https://orcid.org/0000-0003-0761-3064)
- Meile Le (ORCID: https://orcid.org/0009-0008-4896-5684)
- Vũ Quang Huy (ORCID: https://orcid.org/0000-0003-3509-1814)
- Jorge-Eduardo Ponce-Zea (ORCID: https://orcid.org/0000-0002-9058-7727)
- Seri Choi (ORCID: https://orcid.org/0000-0002-0295-7370)
- Jin‐Pyo An (ORCID: https://orcid.org/0000-0002-7143-9497)
Institutions
- Seoul National University (KR)
Publication Details
- Journal
- Nutrients
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3390/nu17213321
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea