Potential Antiviral Compounds from Hippeastrum puniceum Bulb Against Yellow Fever Virus: Bioassay-Guided Fractionation and In Silico Pharmacokinetic Analysis
Our results underscore the importance of further investigations <i>in vitro</i>, particularly assays exploring the synergy among the annotated compounds against YFV. The integration of bioassay-guided fractionation of active plant extracts with computational analyses emerges as a promising strategy for the discovery of natural products with therapeutic potential against yellow fever, a reemerging disease.
Authors
- Alisson Samuel Portes Caldeira (ORCID: https://orcid.org/0000-0002-0998-1939)
- Carlos Leomar Zani (ORCID: https://orcid.org/0000-0003-1859-177X)
- Carlos Eduardo Calzavara-Silva (ORCID: https://orcid.org/0000-0002-1406-6401)
- Tânia Maria de Almeida Alves (ORCID: https://orcid.org/0000-0002-0582-3968)
- Emerson Castro (ORCID: https://orcid.org/0000-0002-3210-7342)
- Naiara Clemente Tavares
- Douglas E. V. Pires (ORCID: https://orcid.org/0000-0002-3004-2119)
- Carolina Colombelli Pacca (ORCID: https://orcid.org/0000-0001-9252-2137)
- Thaís M. Acácio (ORCID: https://orcid.org/0000-0002-1871-9860)
- Eliza Flores-Souza (ORCID: https://orcid.org/0000-0002-6548-147X)
- Jaquelline Germano de Oliveira (ORCID: https://orcid.org/0000-0002-0487-8748)
- Tamiris Vanessa Miguel de Souza
Institutions
- The University of Melbourne (AU)
- Instituto de Ensino e Pesquisa Santa Casa (BR)
Publication Details
- Journal
- Molecules
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3390/molecules30214149
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais