Nickel-Catalyzed Carbonylation Reaction of Aryl <i>N</i>-Tosylaziridines with Arylboronic Acids toward β-Amino Ketones
A novel nickel-catalyzed carbonylation reaction of aryl N-tosylaziridines with arylboronic acids has been explored for the synthesis of β-amino ketones. By using formic acid as the CO source, a variety of β-amino ketones were obtained in moderate to excellent yields. This approach features high regioselectivity, good functional group tolerance, and a CO gas-free operation. It provides a good supplement for the ring-opening transformation of aziridines through a nickel-catalyzed radical carbonylation process.
Authors
- Xiao‐Feng Wu (ORCID: https://orcid.org/0000-0001-6622-3328)
- Pengfei Ji (ORCID: https://orcid.org/0000-0002-8109-7929)
- Chen-Yang Hou
- Tong Li (ORCID: https://orcid.org/0000-0003-4500-2977)
- Xinxin Qi (ORCID: https://orcid.org/0000-0003-4917-1524)
- Boyu Yao
Institutions
- Zhejiang Sci-Tech University (CN)
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Leibniz Institute for Catalysis (DE)
- Ingenierie des Materiaux polymeres (FR)
- Dalian National Laboratory for Clean Energy (CN)
- Interface (United Kingdom) (GB)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-07-18
- DOI
- https://doi.org/10.1021/acscatal.5c03618
- Citations
- 5
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 4.68