A 40-Year Regional Study of Cleft Lip and/or Palate Incidence in Tokai, Japan
This long-term regional surveillance study demonstrates a stable incidence of CL/P in the Tokai region in spite of demographic shifts, such as declining birth rates and rising maternal age. These findings emphasize the value of sustained, regionally based congenital anomaly monitoring systems in guiding health policy, perinatal counseling, and genetic risk assessment.
Authors
- Kumiko Fujiwara (ORCID: https://orcid.org/0000-0001-9158-4141)
- Hideto Imura (ORCID: https://orcid.org/0000-0002-0011-8223)
- Nagato Natsume (ORCID: https://orcid.org/0000-0001-7943-2284)
- Chisato Sakuma
- Tatsuji Niimi (ORCID: https://orcid.org/0000-0003-3007-0686)
- Hiroo Furukawa
- Nagana Natsume
- Ken Kitagawa
Institutions
- Aichi Gakuin University (JP)
- Osaka University Hospital (JP)
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-10-22
- DOI
- https://doi.org/10.7759/cureus.95191
- Primary Topic
- Cleft Lip and Palate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00