Venous Thromboembolism in Inherited Platelet Disorders: A Clinical Challenge

Inherited platelet disorders (IPDs) are rare hematological conditions characterized by abnormal platelet function or number, predisposing patients to bleeding. Even if they apparently lower the risk of venous thromboembolism (VTE), this is not abolished in these patients, and may represent a potential cause of mortality. VTE prevention and treatment in these patients is particularly challenging due to the delicate balance between thrombosis and bleeding risks. Here, we summarize current evidence on the incidence, risk factors, and management strategies for VTE in IPD patients, with a focus on the perioperative setting.