SAT-336 Trends in Thyroid and Cardiac Disorders Mortality; Pre- and Post-COVID: Insights from 1999 to 2022 in the United States

Abstract Disclosure: I. Ahmad: None. M. Haider: None. S. Cheema: None. M. Raza: None. H. Javaid: None. H. Ijaz: None. M. Hassan: None. M. Rizwan: None. M. Kakakhel: None. H. Ilyas: None. D. Rizwan: None. A. Akram: None. Background In March 2020, the WHO declared the coronavirus disease 2019 (COVID-19) to be a pandemic. The COVID-19 which has a profound impact on the healthcare system, also leads to changes in the prevalence and outcomes of both the conditions because imbalance in thyroid function can lead to a wide range of cardiac complications. This study aims to analyze the pre-COVID and post-COVID trends in mortality associated with both thyroid disorders and cardiac disorder in the United States from 1999 to 2022. Methods Data was extracted from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER). The analysis of Multiple Cause of Death Files was conducted from 1999 to 2022 to identify fatalities associated with both thyroid and cardiac disorder. Crude rates and age-adjusted mortality rates (AAMRs) per 100,000 populations were calculated for variables including year, race and ethnicity, and geographic regions. Joinpoint regression analysis was utilized to evaluate annual percent changes (APCs) and average annual percent changes (AAPCs). Results From 1999 to 2022, a total of 342793 thyroid and cardiac disorders related deaths were reported. An overall increasing trend was observed in AAMR (4.17, 95% CI 4.1 to 4.24) from 1999 to 2022. A significant decrease in AAMR was observed initially from 1999 to 2016 with an APC of -1.2 (95% CI -1.6 to -0.8). However, an alarming rise was observed from 2016 to 2022 with an APC of 5.74 (95% CI 4.2 to 7.8) with a more noticeable increase starting from the COVID-19 year onwards. This increase in AAMR was pronounced in female patients (AAMR:4.84; 95% CI 4.75 to 4.93), non-Hispanic patients (AAMR: 4.24; 95% CI, 4.16 to 4.3) and in West Census Region (AAMR: 4.46; 95% CI, 4.3 to 4.61).The highest percentage of death of patients occurred in the Large Central Metro and Nursing home followed by Medical Facility. Conclusion Following a decline in mortality rates associated with thyroid and cardiac Disorders from 1999 to 2022, the significant rise from 2016 onwards is alarming especially from COVID-19 year onwards. This upward trend from pandemic year underscores the importance of further research to address the concerns and the development of more targeted therapies and precautions to implement essential protections against these diseases in the coming years. Presentation: Saturday, July 12, 2025