MON-605 Association of coefficient of variation (CV) with diabetes related distress and hypoglycaemia awareness in Association of British Clinical Diabetologist Audit

Abstract Disclosure: H. Deshmukh: HD has received travel award from Abbott to present at various meetings. E. Wilmot: E.G.W. has received personal fees from Abbott, AstraZeneca, Dexcom, Eli Lilly, Embecta, Insulet, Medtronic, Novo Nordisk, Roche, Sanofi, Sinocare, and Ypsomed and research support from Abbott, Embecta. C. Walton: C.W. has a spouse/partner serving on the advisory panel for Celgene and on the speakers bureaus for LEO Pharma and Novartis. R. Ryder: R.E.J.R. serves on the advisory panel for Novo Nordisk and on the speakers bureau for BioQues. T. Sathyapalan: . T.S. serves on the speakers bureau for Novo Nordisk Foundation. Background: The objective of this study was to study the association between coefficient of variation (CV), a measure of glycemic variability, with diabetes-related distress and hypoglycaemia awareness in people living with type 1 diabetes Methods: We used data from the Association of British Clinical Diabetologist FreeStyle Libre audit. Regression models were performed to explore associations between CV, diabetes-related distress, hypoglycaemia awareness (Gold Score), adjusting for clinical characteristics such as age, gender, BMI, and diabetes duration. Results: The study consisted of 162 participants with a mean age 48.3 (17.9) years and a mean duration of diabetes 17.5(13.6) years. The mean CV was 34.4(8.9)% with 55.2% of participants demonstrating a CV below 36%. The CV was significantly correlated with Gold score (r2 = 0.239, p = 0.003) but not with diabetes related distress (P=0.5). Regression analysis showed that higher CV was associated with higher Gold score (β = 0.031, p = 0.017). For diabetes-related distress, CV demonstrated a borderline association (β = 0.019, p = 0.060). Conclusions: These real-world data show that CV is associated with hypoglycaemia awareness. These findings underscore the importance of glycaemic variability in optimizing diabetes in clinical practice. Presentation: Monday, July 14, 2025