USP9X-triggered ferroptosis mediates follicular atresia via deubiquitinating Beclin1 in chicken
Our findings provide the evidence that the USP9X-Beclin1 axis regulates autophagy-dependent ferroptosis during avian follicular atresia. These insights reveal novel molecular targets and potential genetic markers for improving reproductive efficiency in chicken breeding programs.
Authors
- Shunshun Han (ORCID: https://orcid.org/0000-0001-9394-1165)
- Huadong Yin (ORCID: https://orcid.org/0000-0002-9546-5753)
- Zhuanjian Li (ORCID: https://orcid.org/0000-0002-7595-0604)
- Wenjuan Wang (ORCID: https://orcid.org/0000-0002-5445-0985)
- Yao Zhang (ORCID: https://orcid.org/0000-0002-0943-090X)
- Yuqi Chen (ORCID: https://orcid.org/0000-0002-5635-3409)
- Can Cui (ORCID: https://orcid.org/0009-0000-7291-8150)
Institutions
- Sichuan Agricultural University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s40104-025-01269-8
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00