SAT-505 The Uneven Picture of Paragangliomas: Incidence Trends Across Racial Groups

Abstract Disclosure: S. Keritum: None. J. kenmoe: None. A. Shrestha: None. H. Ghumman: None. The Uneven Picture of Paragangliomas: Incidence Trends Across Racial GroupsShereen Keritum1, Jerry Kenmoe1, Anjela Shrestha1, Harneet Ghumman11. Michigan State University/McLaren Regional Medical Center Background: Paragangliomas are rare neuroendocrine tumors with limited data on racial disparities in theirincidence. This study examines trends in paraganglioma incidence and racial disparities in theUnited States using data from the Surveillance, Epidemiology, and End Results (SEER) databasefrom 2000 to 2021. Methods: A retrospective cohort study was conducted using SEER data from 2000–2021. Incidence rateswere calculated per 100,000 person-years and stratified by race, including non-Hispanic White,non-Hispanic Black, non-Hispanic American Indian/Alaska Native, non-Hispanic Asian/PacificIslander, and Hispanic (all races). Temporal trends were analyzed using Joinpoint regression toidentify significant changes in incidence over time. Results: Racial stratification revealed incidence rates of 0.05 for non-Hispanic Whites, 0.08 for non-Hispanic Blacks, 0.03 for non-Hispanic American Indian/Alaska Native, 0.04 for non-HispanicAsian/Pacific Islander, and 0.04 for Hispanics. A significant rise in paraganglioma incidence wasobserved across all racial groups from 2019 to 2021, although insufficient data were available tocharacterize trends for non-Hispanic Asians and American Indian/Alaska Natives in theJoinpoint analysis. Conclusions: The incidence of paragangliomas remained stable from 2000 to 2019 but increased significantlyfrom 2019 to 2021 across all racial groups. These findings highlight the need for further researchto elucidate the factors driving this rise, particularly in underrepresented racial groups, wheredata limitations pose challenges for trend analysis. Figure 1: Incidence of Paragangliomas by Race 2000-2021 Presentation: Saturday, July 12, 2025