Advancing Lung Cancer Staging: Integrating IASLC Recommendations and Bioinformatics to Delineate Tumor Origins
Small-scale panel sequencing of biopsy material allows unambiguous clonality determination in three of four cases. Large-scale sequencing resolves approximately half of inconclusive cases. Our bioinformatic method reduces inconclusive pairs to 2% even with small-scale NGS. It is made publicly available as a Shiny App. Clonality is reflected in survival data and therefore pivotal in daily clinical practice.
Authors
- Bauke Ylstra (ORCID: https://orcid.org/0000-0001-9479-3010)
- D. Kazdal
- M. Thomas
- A-L Volckmar
- Felix Herth (ORCID: https://orcid.org/0000-0002-7638-2506)
- P. Christopoulos
- Markus Ball (ORCID: https://orcid.org/0000-0002-2312-8360)
- A Stenzinger
- Teodora Radonic (ORCID: https://orcid.org/0000-0002-6015-5202)
- M. Allgäuer
- L. Bubendorf
- M. Kirchner
- Claus Peter Heußel (ORCID: https://orcid.org/0000-0001-5809-5733)
- H. Winter
- Klaus Kluck (ORCID: https://orcid.org/0009-0001-1000-8052)
- S. Peters
- Jan Budczies (ORCID: https://orcid.org/0000-0002-6668-5327)
- Paul Hofman (ORCID: https://orcid.org/0000-0003-0431-9353)
- Peter Schirmacher
Institutions
- German Cancer Research Center (DE)
- University of Basel (CH)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Centre Hospitalier Universitaire Vaudois (CH)
- Centre Hospitalier Universitaire de Nice (FR)
- National Center for Tumor Diseases (DE)
- German Center for Lung Research (DE)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Thoracic Oncology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.jtho.2025.10.010
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Agence Nationale de la Recherche
- Deutsches Zentrum für Lungenforschung