SAT-506 Sex-Independent Surge: Trends in Malignant Pheochromocytoma Incidence (2000-2021)

Abstract Disclosure: S. Keritum: None. J. kenmoe: None. A. Shrestha: None. H. Ghumman: None. Background: Malignant pheochromocytomas are rare catecholamine-secreting tumors with significant clinicalimplications. Limited data exist on their incidence trends and potential sex-based disparities. This study investigates the incidence of malignant pheochromocytomas and differences by sex inthe United States using SEER data from 2000 to 2021. Methods: A retrospective analysis of malignant pheochromocytoma cases from the SEER database wasconducted. Incidence rates were calculated per 100,000 person-years for males and females.Joinpoint regression was used to analyze temporal trends and identify signif icant changes inincidence over the study period. Results: From 2000 to 2021, the overall incidence of malignant pheochromocytomas remained stable at0.06 per 100,000 person-years for both males and females. From 2000 to 2019, no significantchanges in incidence were observed. However, a sharp and statistically significant rise inincidence was noted from 2019 to 2021 across both sexes. No significant sex-based disparities inincidence rates were identified throughout the study period. Conclusions: The incidence of malignant pheochromocytomas remained stable over two decades but showeda notable increase from 2019 to 2021, with no disparities observed between males and females.These findings highlight the importance of further research into potential drivers of this rise,including advancements in diagnostic technologies and changes in disease awareness.Understanding these trends is critical for improving early detection and management strategiesfor this rare malignancy. Figure 1: Incidence of Malignant Pheochromocytoma by Sex 2000-2021 Presentation: Saturday, July 12, 2025