SAT-504 A Two-Decade Perspective on Paragangliomas: Stable Incidence with a Surprising Surge in Recent Years

Abstract Disclosure: S. Keritum: None. J. kenmoe: None. A. Shrestha: None. H. Ghumman: None. Background: Paragangliomas are rare neuroendocrine tumors arising from the autonomic nervous system.Despite their low incidence, understanding their trends and potential disparities by sex is criticalfor clinical and public health strategies. This study investigates the incidence of paragangliomasin the United States, with a focus on sex-based disparities, using data from the Surveillance,Epidemiology, and End Results (SEER) database from 2000 to 2021. Methods: A retrospective analysis of paraganglioma incidence data was performed using SEER*Statsoftware. Cases diagnosed between 2000 and 2021 were included. Incidence rates werecalculated per 100,000 person-years and stratified by sex (male vs. female). Temporal trendswere analyzed using Joinpoint regression models to identify significant changes in incidenceover time. Results: The overall incidence of paragangliomas from 2000 to 2021 was stable at 0.05 per 100,000person-years for both males and females. From 2000 to 2019, no significant change in incidencewas observed. However, a sharp and statistically significant increase in incidence was notedfrom 2019 to 2021. This rise was consistent across both sexes, with no significant sex-baseddisparities identified over the study period. Conclusions: The incidence of paragangliomas remained stable from 2000 to 2019 but exhibited a markedincrease from 2019 to 2021. This trend underscores the need for further investigation intopotential factors driving this rise, including advances in diagnostic techniques and changes indisease awareness. Understanding these trends is crucial for guiding early detection andmanagement strategies. Figure 1: Incidence of Paragangliomas by Sex 2000-2021 Presentation: Saturday, July 12, 2025