SAT-818 Spermidine in Health and Diseases

Abstract Disclosure: H.M. Heshmati: None. R. Jarisch: None. Background: Spermidine is a naturally occurring polyamine that was discovered in human semen in 1678. The sources of spermidine are endogenous (e.g., synthesis by gut microbiome) or exogenous (e.g., dietary intake and supplements). The synthesis of spermidine is stimulated by fasting. Spermidine plays an important role in cellular physiology and may contribute to the pathogenesis of several diseases. This review presents an update on spermidine in health and diseases. Methods: A systematic search of literature was conducted using the search terms spermidine, health, longevity, and diseases. Results: Spermidine plays a key role in cellular growth, regeneration, and regulation. It induces autophagy through the inhibition of several acetyltransferases, has anti-inflammatory and antioxidant properties, and positively affects the cell cycle. Spermidine has the ability to increase longevity by maintaining cellular health, fighting against several age-related diseases (e.g., ischemic heart disease, stroke, chronic obstructive pulmonary disease, cancer, respiratory infection, type 2 diabetes, osteoporosis, and dementia), and preventing premature aging. In normal subjects, the median of serum spermidine level is around 25 ng/mL and the level decreases with aging. Serum spermidine level can be a potential biomarker for the diagnosis and prognosis of several diseases. High serum spermidine level may indicate a lower risk of mild cognitive impairment (3,774 participants aged > 35 years with no history of dementia), but has been linked to an increased risk of stroke. In acute myocardial infarction, higher serum spermidine level predicts lower risk of recurrence. Low serum spermidine level may be associated with several medical conditions including cardiovascular and neurodegenerative diseases. Considering the physiological properties of spermidine, a diet rich in spermidine (e.g., plant-derived foods and aged cheese) and spermidine supplements (spermidine in capsule) present an attractive approach for preventing or postponing the occurrence and the severity of age-related diseases and for increasing longevity. However, additional investigations assessing the consequences of chronic spermidine administration are needed before proposing clinical guidelines. Conclusion: Spermidine plays an important role in physiology and in pathogenesis of several diseases. It has anti-inflammatory, neuroprotective, anti-cancer, and anti-aging properties. Its serum level has the potential to be used as a biomarker for disease diagnosis and prognosis. Diet rich in spermidine and spermidine supplements can be beneficial in preventing or postponing the occurrence and the severity of several age-related diseases and in increasing longevity. However, further research is necessary to better evaluate the risks and benefits of long-term spermidine intake. Presentation: Saturday, July 12, 2025