SUN-594 Demographic and Regional Trends and Disparities in Type 2 Diabetes Mortality in US Adults Aged ≥35 from 1999 to 2023

Abstract Disclosure: A. Shafaq: None. H. Siddque: None. A. Raza: None. M. Fatima: None. F. Fatima: None. I. Shahid: None. U. khan: None. Background: Type 2 diabetes mellitus (T2DM) is a significant health burden in middle-aged and older adults, contributing significantly to the increased mortality worldwide. In 2019, T2DM contributed to 476 million prevalent cases, 1.37 million deaths, and 67.9 million disability-adjusted life years globally, and is expected to continue growing in the upcoming years due to the increasing prevalence of comorbidities, poor dietary habits, sedentary lifestyles, and aging population. This study aims to explore the rising trends in mortality attributed to T2DM and the disparities across various demographic and regional variables across the US from 1999 to 2023. Methods: Using the CDC WONDER mortality database, we extracted the death certificate data as age-adjusted mortality rates (AAMRs) per 100,000 individuals aged ≥35 for T2DM mortalities from 1999 to 2023. Change in trends was calculated using the Joinpoint Regression Program as annual percentage change (APC) and average APC (AAPC). Results: From 1999 to 2023, T2DM caused a total of 2,028,408 deaths among adults aged ≥35, with an overall increasing trend [AAPC: 3.67% (3.18 - 4.42)]. Males showed a greater rise in mortality than females over the study period [3.95% (3.45 - 4.77) vs 3.23% (2.75 - 3.93)], the individual trends were significant; however, the difference between the trends was not significant. Among racial and ethnic groups, non-Hispanic (NH) Asians or Pacific Islanders exhibited the highest increase in mortality of 5.26% (4.61 - 6.08), followed by Hispanics or Latinos [4.03% (3.40 - 4.80)], NH Whites [3.55 (3.16 - 4.09)], NH Blacks or African Americans [3.43% (2.72 - 4.57)], and NH American Indians or Alaska Natives [2.80% (1.95 - 3.66)]. Regionally, the West showed the highest mortality among all other census regions [5.63% (5.22 - 6.06)], which was significantly higher than the other regions. This was followed by the South [3.33% (2.93 - 3.88)], the Midwest [2.89% (2.30 - 3.67)], and the Northeast [1.84% (1.21 - 2.34)]. The Northeast had a significantly lower rise in mortality than the South and the West, but not the Midwest. The rise in mortality was significantly higher for the 35-44 years age group [7.28% (6.18 - 9.46)] compared to the subsequent ten-year age groups, in which the rise in mortality decreased subsequently with increasing age. Conclusion: From 1999 to 2023, T2DM-related mortality showed a consistent rise with males experiencing a greater rise than females. The highest increase in mortality was observed in the West, NH Asians or Pacific Islanders, and the younger adult age group 35-44 years. This highlights the need for targeted health policy measures to reduce these disparities and alleviate T2DM-related health burden. Presentation: Sunday, July 13, 2025