SAT-641 Clinical Outcomes for Patients with PCOS and Type 2 Diabetes: An Analysis of the National Inpatient Sample

Abstract Disclosure: M. Singh: None. T. Elias: None. D.C. Thor: None. S. Prasad: None. Clinical Outcomes: for Patients with PCOS and Type 2 Diabetes: An Analysis of the National Inpatient Sample Introduction: As clinicians continue to improve their recognition and management of polycystic ovarian syndrome (PCOS), it remains imperative to understand the health outcomes for these patients over time. Limited data is available on the comorbid correlations for the PCOS population. Objectives: We sought to examine the National Inpatient Sample (NIS) database to describe in-hospital outcomes among patients with PCOS and type II diabetes mellitus (DM). Methods: Data were extracted from the NIS database from 2019 and 2020. The NIS was searched for hospitalizations of all patients greater than 18 years old who had PCOS. We then analyzed the outcomes of patients with DM. Multivariate logistic regression analysis was used to adjust for confounders. The primary outcome was inpatient mortality and secondary outcomes were annotated accordingly. SPSS software was used for statistical analysis, and all results were powered to p<0.001. Results: This study included 32,385 patients with PCOS, of which 243 (0.75%) were identified as diabetic. Multivariate regression demonstrated that DM patients with PCOS did not have confidently higher inpatient mortality (OR 1.012, CI 0.989-1.035). On secondary analysis, PCOS patients with DM were more likely to have anemia (OR 1.011, CI 1.009-1.014), thrombocytopenia (OR 1.016, CI 1.008-1.025), peripheral artery disease (OR 1.116, CI 1.069-1.165), hypertension (OR 1.020, CI 1.012-1.028), chronic kidney disease (OR 1.030, CI 1.018-1.042), acute renal failure (OR 1.014, CI 1.008-1.021), pancreatitis (OR 1.014, CI 1.002-1.027), pericarditis (OR 1.062, CI 1.012-1.114), esophagitis (OR 1.011, CI 1.009-1.014), Crohn’s disease (OR 1.024, CI 1.003-1.045), connective tissue disease (OR 2.374, CI 2.118-2.661), all-cause arrhythmias (OR 1.014, CI 1.006-1.022), all-cause sepsis (OR 1.014, CI 1.010-1.019), all-cause coagulopathy (OR 1.033, CI 1.021-1.045), all-cause heart failure (OR 1.021, CI 1.011-1.031), all-cause stroke (OR 1.014, CI 1.006-1.022), and all-cause myocardial infarction (OR 1.023, CI 1.008-1.039). Conclusion: In this nationally-representative, population-based retrospective cohort study, hospitalized patients with PCOS and DM were associated with greater morbidity but not higher mortality. Further analysis and/or discussion is necessary to improve the care of this potentially underserved population. Presentation: Saturday, July 12, 2025