SAT-565 Gender-Specific Trends in Mortality and Disability-Adjusted Life Years (DALYs) of Chronic Kidney Disease Due to Type 1 Diabetes Among Adults Aged 55 and Older (1990-2021): A Global Burden Of Disease Study

Abstract Disclosure: M. Munir: None. G. Flocco: None. H. Ahmad: None. A. Zahid: None. J. Ikram: None. F. Ahmed: None. M. kakakhel: None. M. Ali: None. A. Cheema: None. Chronic kidney disease (CKD) due to type 1 diabetes mellitus (T1DM) poses a significant global health challenge, particularly in older adults. Despite its rising burden, comprehensive assessments of gender-specific trends in mortality and Disability-Adjusted Life Years (DALYs) remain scarce, underscoring the need for targeted analysis. We utilized data from the Global Burden of Disease (GBD) Study to investigate gender-specific trends in DALYs and mortality rates linked to CKD due to T1DM in adults aged 55 and older from 1990 to 2021. Trends were evaluated using the Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC), both presented with 95% confidence intervals (CI), and statistical significance was assessed through p-values. CKD due to T1DM has imposed a substantial burden of morbidity and mortality over the past three decades. In 1990, the DALYs rates were 90.45 per 100,000 men and 64.71 per 100,000 women. By 2021, these rates increased to 103.31 per 100,000 in men and 71.13 per 100,000 in women. Similarly, mortality due to CKD caused by T1DM has risen significantly. In 1990, CKD due to T1DM caused 9,205 deaths in men compared to 7,744 deaths in women. By 2021, this burden escalated, with 24,023 deaths reported in men and 18,851 in women. The AAPC analysis demonstrated that the burden of CKD due to T1DM consistently remained higher in men compared to women from 1990 to 2021. Among men, DALYs increased significantly (AAPC: 0.45; 95% CI: 0.42-0.48; p < 0.000001), alongside a notable rise in mortality rates (AAPC: 0.51; 95% CI: 0.49-0.54; p < 0.000001). Similarly, in women, DALY rates also showed a significant upward trend (AAPC: 0.31; 95% CI: 0.29-0.33; p < 0.000001), accompanied by an increase in mortality rates (AAPC: 0.35; 95% CI: 0.32-0.37; p < 0.000001). The APC analysis revealed additional significant trends. Among men, DALY rates exhibited the most substantial increase between 1996 and 2003 (APC: 1.07; 95% CI: 0.95-1.34), a trend mirrored in women during the same period (APC: 1.09; 95% CI: 0.97-1.23). Interestingly, the highest increases in mortality rates were also observed between 1996 and 2003 for both men (APC: 1.08; 95% CI: 0.94-1.31) and women (APC: 1.08; 95% CI: 0.93-1.29). These findings underscore a period of heightened disease burden for both genders during this timeframe. CKD due to T1DM has led to a consistently rising burden of DALYs and mortality over the past three decades, with men experiencing a higher burden than women. These findings emphasize the urgent need for gender-specific strategies to address this growing public health challenge. Presentation: Saturday, July 12, 2025