MON-710 Influcence of Gender on Weight Loss after Mini Gastric Bypass Surgery

Abstract Disclosure: Y. Sofer: None. I. Sarig: None. Y. Greenman: None. W. Abu Ahmad: None. Background: Bariatric surgery (BS), is a highly effective and cost-efficient intervention for achieving long-term weight loss in individuals with obesity. In recent years, the Mini Gastric Bypass (MGB) procedure has gained popularity in Israel, accounting for approximately 70% of all bariatric surgeries performed. Assessing the success of BS often involves measuring the total and mean percentage of excess weight loss (%EWL). While various factors predict %EWL, the impact of gender on this outcome remains controversial, with conflicting results in both general BS and specifically in MGB studies. Aims: Examine the impact of gender on MGB outcomes in Israeli patients up to two years following the operation. Methods: We conducted a retrospective cohort study among patients who underwent MGB procedure at a single tertiary hospital. Data was obtained from medical records of the patients who underwent both preoperative and postoperative evaluations in obesity clinic between 2013 to 2023. The primary outcome was the %EWL at 6-month, 1-year, and 2-year intervals following the procedure. Using a multivariant analysis we calculated weight loss and %EWL according to gender. Results: A total of 187 patients were included, 133 (71.1%) females, 54 (28.9%) males. Median age was 46.7 (34.8-55.5) years for women and 49 (39.49-58.8) years for men. Over time, participants experienced significant weight reductions. At 6-12 months post-surgery, the total weight decreased by 20.4 (15.1-26.2) kg relative to the baseline, and by 1-2 years, median weight loss was 36.2 (29-48.1) kg. Gender differences were observed, where males experienced higher weight reductions over time. At 6-12 months, males lost 20.4 (15.1-26.2) kg whereas women lost 15.4 (10.4-21.4) kg. Likewise, at 1-2 years, males experienced a weight reduction that was 12 kg higher than that of females [(44.4 (36.8-51.7) kg compared to 32.4 (24.7-40.6) kg; p<0.01]. This difference remained significant even after multivariate analysis, which accounted for factors such as age, underlying chronic conditions (including diabetes, dyslipidemia, and metabolic dysfunction-associated steatotic liver disease, OSA), glucose and HbA1c levels and medications (insulin, statins, calcium channel blockers). %EWL was also significantly higher for men, 85+/-29% compared to 77+/-28% in women. Conclusions: This study highlights the significant impact of gender on weight loss outcomes following MGB. Further research is warranted to explore the underlying mechanisms and potential implications for treatment strategies and patient counseling to optimize outcomes for both male and female patients. Presentation: Monday, July 14, 2025