SAT-517 The Effectiveness of Circadian-Based Time-Restricted Eating on Improving Glycemic Control and Weight Loss Among Filipinos With Type 2 Diabetes Mellitus

Abstract Disclosure: B.A. Vista: None. O.C. Dampil: None. Background: A number of studies highlight the potential benefit of Time-Restricted Eating (TRE) for glycemic control. Circadian-based time-restricted eating (CBTRE), a form of TRE aligns food intake with the body’s circadian rhythm. We evaluated the effectiveness of CBTRE on improving glycemic control and cardiometabolic parameters in patients with Type 2 Diabetes Mellitus (T2DM). Methods: This randomized controlled trial involved 149 overweight or obese Filipino adults (aged ≥19 years) with T2DM, recruited from the outpatient clinic of a tertiary hospital in Quezon City, Philippines. Participants were randomly assigned to either: (1) CBTRE combined with the Filipino plate method or (2) to the Filipino plate method alone. All participants followed a diet based on the Filipino plate method, while those in the CBTRE group were further instructed to consume their meals within a timeframe of 2 hours after waking and 3 hours before bedtime. Baseline data were collected, and follow-up assessments, including HbA1c, fasting blood sugar (FBS), weight, BMI, waist circumference, and lipid profiles, were performed after 12 weeks. Results: Glycemic parameters, including HbA1c and FBS, improved significantly in both groups. In the CBTRE group, HbA1c dropped from 6.90% to 6.60% (p < 0.001), and FBS decreased from 122.73 mg/dL to 116.80 mg/dL (p = 0.015). The Plate Method group showed similar improvements, with HbA1c from 6.90% to 6.70% (p = 0.002) and FBS from 120.00 mg/dL to 111.00 mg/dL (p = 0.047). Both groups demonstrated significant improvements in weight, BMI, and waist circumference. The CBTRE group showed significant weight reduction (73.40 kg to 70.00 kg, p = 0.010) and BMI decrease (27.52 kg/m² to 26.57 kg/m², p = 0.011). Similarly, the Plate Method group had weight loss (68.00 kg to 68.00 kg, p = 0.017) and decrease in BMI (26.26 kg/m² to 26.35 kg/m², p = 0.015). Waist circumference significantly decreased in both groups, with the CBTRE group improving from 37.50 cm to 37.00 cm (p < 0.001) and the Plate Method group from 37.00 cm to 36.00 cm (p < 0.001). In the CBTRE group, total cholesterol decreased significantly from 153.40 mg/dL to 146.44 mg/dL (p = 0.014), and LDL dropped from 82.43 mg/dL to 68.03 mg/dL (p = 0.002). The Plate Method group showed a significant reduction in LDL from 84.00 mg/dL to 72.00 mg/dL (p = 0.036). Triglycerides and HDL levels remained unchanged in both groups (p > 0.05). Median compliance was similar between groups (CBTRE: 54 days, Plate Method: 48 days, p = 0.270). Conclusion: Although both CBTRE and the Filipino Plate Method effectively improved glycemic control and cardiometabolic health, there is no clear superiority of CBTRE over Filipino Plate Method alone. Presentation: Saturday, July 12, 2025