OR10-06 Mortality and Hospitalization Outcomes in Patients Aged 80 and Older Receiving Osteoporosis Treatment After Fracture

Abstract Disclosure: G. Flocco: None. N. Vigneswaramoorthy: None. D. Al-Husni: None. A. Sanko Posada: None. M. Albliwi: None. A. Cheema: None. A. Vignarajah: None. W. Marcos Valencia: None. Many osteoporotic fractures such as hip and vertebral fractures have elevated morbidity and mortality. There is debate regarding the impact in outcomes of initiation of osteoporosis treatment in very elderly patients (age 80 years old or older). This observational study used the TriNextX health research database to identify patients diagnosed with osteoporosis who suffered a fragility fracture at age 80 years old or older. Patients were divided into 2 cohorts: cohort 1 included 54,498 patients who were subsequently treated with bisphosphonates, denosumab, raloxifene, or teriparatide, and cohort 2 included patients who did not receive any of those treatments (78,448 patients). Patients were followed for 5 years after the index fracture. Propensity score matching adjusted for key demographics and comorbidities (hypertension, diabetes, ischemic heart disease, obesity, heart failure, stroke, COPD, CKD, hyperlipidemia, rheumatoid arthritis, neoplasm, and vitamin D deficiency), resulting in 44,338 matched pairs. Measure of association analysis and Kaplan-Meier survival analysis were conducted for a 5 year follow up period after index event (osteoporotic fracture). Outcomes included occurrence of hospitalization within 5 years and death within 5 years. The analysis showed that patients who suffered an osteoporotic fracture at age 80 years old or later and received subsequent osteoporosis treatment (Cohort 1) had lower incidence of hospitalizations (18,142 vs 20,385 patients, with an odds ratio of 0.814 and 95% CI 0.792,0.836), and experienced lower all-cause mortality (11,073 vs 12,479 patients, OR 0.850, 95% CI 0.825, 0.876). The data obtained in this large U.S study suggests that, among patients with osteoporosis who suffer a fragility fracture at age 80 years old or later, those who receive treatment for osteoporosis have a lower incidence of all-cause mortality and lower incidence of hospitalizations in the 5-year follow-up period, supporting the initiation of osteoporosis treatment in this elderly population. Presentation: Saturday, July 12, 2025