Structural changes from wild-type define tumor-rejecting neoantigens
Given the paucity of shared mutations, this work supports the need for personalized neoantigen vaccines in cSCC. To facilitate further discovery, we provide a clinically relevant mouse cSCC model with two defined neoantigens that mediate tumor rejection. Structural changes in the exposure of features that promote T cell receptor recognition defined tumor-rejecting neoantigens. Incorporation of structural modeling to predict changes in T cell receptor accessibility is anticipated to improve the selection of neoantigens for inclusion in personalized cancer vaccines.
Authors
- Anngela C. Adams (ORCID: https://orcid.org/0000-0002-0205-6839)
- Lauren M Herrmann (ORCID: https://orcid.org/0000-0002-0452-4368)
- Kenneth H. Buetow (ORCID: https://orcid.org/0000-0003-4439-0939)
- Denise J. Roe (ORCID: https://orcid.org/0000-0001-6989-6579)
- Janko Nikolich‐Žugich (ORCID: https://orcid.org/0000-0001-5830-5323)
- Elizabeth S. Borden (ORCID: https://orcid.org/0000-0002-2665-0218)
- Chad A. Brambley (ORCID: https://orcid.org/0000-0001-9429-2048)
- Sandip Ashok Sonar (ORCID: https://orcid.org/0000-0001-6193-5529)
- Alysia Hughes (ORCID: https://orcid.org/0000-0003-1717-0818)
- Anne M. Macy (ORCID: https://orcid.org/0000-0003-4508-3658)
- Aaron R. Mangold (ORCID: https://orcid.org/0000-0001-6873-1705)
- Karen Taraszka Hastings (ORCID: https://orcid.org/0000-0003-1502-8033)
- Brian M. Baker (ORCID: https://orcid.org/0000-0002-0864-0964)
- Xing Li (ORCID: https://orcid.org/0000-0002-8541-8363)
- Tao Ma (ORCID: https://orcid.org/0000-0002-7094-6868)
- Melissa Wilson (ORCID: https://orcid.org/0000-0002-5391-7838)
Institutions
- University of Notre Dame (US)
- University of Arizona (US)
- University of Phoenix (US)
- Phoenix VA Health Care System (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- University of Arizona Cancer Center
- Phoenix College (US)
- Arizona State University (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-013148
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- American Skin Association
- Arizona State University
- University of Arizona
- National Institutes of Health