SAT-125 Impact of Polycystic Ovary Syndrome and Impaired Glucose Tolerance on Preeclampsia Incidence and Birthweight Outcomes: Insights from the Born in Bradford Study

Abstract Disclosure: H. Deshmukh: None. E. Waife: None. A. Rana: None. E. Ssemmondo: None. T. Sathyapalan: None. Objective: The objective of this study was to investigate the interplay between Polycystic Ovary Syndrome (PCOS), Impaired Glucose Tolerance (IGT), preeclampsia, and birthweight outcomes in a large cohort of pregnant women.Methods: We utilized data from the Born in Bradford (BiB) study, integrating maternal health records, metabolomics, pregnancy outcomes, and anthropometric measurements to form a comprehensive dataset. IGT during pregnancy was defined by a 2-hour plasma glucose level between 7.8 and 11.0 mmol/L following a 75-gram oral glucose tolerance test (OGTT). Participants were categorized into four groups based on PCOS status and glucose tolerance: normoglycemic, IGT, PCOS with normoglycemia, and PCOS with IGT. Results: The study comprised 8,922 normoglycemic participants, 22 with PCOS and IGT, 226 with PCOS and normoglycemia, 186 with IGT, and 98 with Gestational Diabetes Mellitus (GDM). The prevalence of IGT was higher in women with PCOS. Significant differences in mean birthweight were observed across these categories (p < 0.001), with normoglycemic pregnancies having the highest mean birthweight (3,236.7 grams) and PCOS with IGT the lowest (3,083.6 grams). Compared to the normoglycemic group, the IGT without PCOS (β = -208.59, p < 0.001), PCOS (β = -117.10, p = 0.010), and PCOS with IGT (β = -369.50, p = 0.009) groups exhibited significantly lower birthweights when controlling for BMI and maternal age. The prevalence of preeclampsia varied across categories, being highest in the PCOS with IGT group, followed by the PCOS group, compared to the normoglycemic population. Conclusion: This study underscores the importance of considering both PCOS and IGT in pregnancy management to mitigate potential adverse outcomes related to preeclampsia and birthweight. Presentation: Saturday, July 12, 2025