Electroreductive α-Aminoalkylation of Sulfonylazoles with Amines and Aldehydes
Here we present the α-aminoalkylation of (methanesulfonyl)azoles with amines and aldehydes under electroreductive conditions to obtain α-arylalkylamines through the radical-radical coupling of α-aminoalkyl radicals, generated by reduction of iminium salts by a cathode, with dihydroazolyl radicals generated by concerted proton-electron transfer (CPET) reduction of sulfonylazoles.
Authors
- Kyohei Yonekura (ORCID: https://orcid.org/0000-0002-5019-6166)
- Eiji Shirakawa (ORCID: https://orcid.org/0000-0002-8564-984X)
- Hibiki Kanda
- Kotaro Sekinishi
Institutions
- Kwansei Gakuin University (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1021/acs.orglett.5c03969
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00