MON-233 The Effects Of Non-nutritive Sweetened Beverages On Glycemic Profiles In Pediatric And Young Adult Diabetics Patients Using Continuous Glucose Monitoring Devices

Abstract Disclosure: S. Sim: None. B. Suh: None. M. Ahn: None. Background: With growing awareness of metabolic diseases, non-nutritive sweeteners (NNS) have gained popularity as sugar alternatives. While NNS-containing beverages are widely promoted as safe option for blood sugar control, their effects on glycemic variability and overall glucose homeostasis remain uncertain, particularly in pediatric and young adult diabetic patients. Limited studies have utilized continuous glucose monitoring (CGM) to assess the real-time impact of NNS intake in this population. This study aimed to investigate the short-term glycemic effects of NNS-containing beverages in pediatric and young adult patients with diabetes using CGM devices. Method: A prospective crossover study was conducted with 27 diabetic patients aged 10 to 29 years, including individuals with type 1 and type 2 diabetes. Each participant underwent two 10-day CGM monitoring periods: one with daily consumption of an NNS-containing beverage (Coca-Cola Zero Sugar, 250mL/day) for five days, followed by a five-day of control period without NNS intake. After three-month washout period, a second crossover period was conducted, reversing the order of NNS consumption and control periods. CGM metrics, including postprandial glucose levels, glycemic variability, Time in Range (TIR), Time above Range (TAR), Time below Range (TBR) and average level were analyzed. Additionally, and glycemic parameters such as fasting blood glucose, HbA1c, insulin and HOMA-IR were measured at each trial. Results: No statistically significant differences were observed in CGM parameters between NNS consumption and control conditions. TIR, TAR, TBR, average glucose, glucose management indicator (GMI), and glycemic variability (GV) did not significantly differ between interventions. The mean CGM value before consumption was 156.88±59.79 mg/dL (mean ± standard deviations), with a post-prandial value (2 hours) was 153.62±1.51 mg/dL. The peak CGM glucose concentration value was 175.42±65.75 mg/dL. Postprandial glucose response within 2 hours after NNS consumption showed no significant difference between NNS consumption and control conditions (p=0.524). Additionally, glycemic parameters such as fasting blood glucose, HbA1c, C-peptide, insulin, and HOMA-IR showed no significant differences between trials. Conclusion: These findings suggests that NNS consumption may have minimal direct effects on postprandial glucose levels in pediatric and young adult diabetes patients. Therefore, NNS-containing beverages may serve as a potential alternative to high glucose containing sugar-sweetened beverages in this population when reducing glucose intake is necessary. Presentation: Monday, July 14, 2025