SUN-262 ATHEROSCLEROTIC CARDIOVASCULAR DISEASE MORTALITY IN PATIENTS WITH UNDERLYING DIABETES MELLITUS: A RETROSPECTIVE STUDY IN THE US FROM 1999 TO 2019

Abstract Disclosure: H. Siddque: None. A. Raza: None. E. Alamgir: None. K. Kumar: None. M. Rehmat: None. E. Zeeshan: None. M. Ahmed: None. A. Younas: None. U. khan: None. Background: Diabetes mellitus (DM) significantly increases the risk of atherosclerotic cardiovascular diseases (ASCVDs) with around 75% of diabetics dying from cardiovascular complications. We aim to assess ASCVD-related mortality patterns in DM in the US from 1999-2019. Methods: Mortality data was obtained from the CDC WONDER database as age-adjusted mortality rates (AAMRs) for ASCVD-related mortality in DM patients. Joinpoint Regression Program was used to calculate the changes in AAMRs as annual percentage change (APC) and average APC (AAPC). Results: ASCVDs caused 453,572 deaths among diabetics in the US from 1999 to 2019, with an overall decreasing trend (AAPC: -1.63%). Females showed a 3-times greater decrease (-2.78%) than males (-0.8%). Non-Hispanic (NH) American Indians had the highest mortality (32.36), and NH Asians had the lowest (12.85). Regionally, the Midwest showed the highest AAMRs (19.86), followed by the Northeast (18.99), the South (18.71), and the West (16.36). Non-metropolitan areas had a higher mortality burden (20.33) than metropolitan areas (18.17). Among states, only Arkansas (64.42%) and Nevada (53.55%) showed an increase in AAMRs, while the rest showed a decrease. Conclusion: The results show a decreasing trend in ASCVD mortality in DM patients in the US; however, increasing mortality has been observed in Arkansas and Nevada, with disparities in all demographics. Targeted interventions should focus on resolving these disparities. Presentation: Sunday, July 13, 2025