Divergence between neural and retinal lineage specification during human brain development by signal transduction
Depletion of S6K1 signaling in the early stage of human brain development drives the formation of retinal cells distinct from cortical neurons. Our findings demonstrate that S6K1 signaling fine-tunes neuronal and retinal lineage specification during brain development.
Authors
- Ning‐Yi Shao (ORCID: https://orcid.org/0000-0003-4231-828X)
- Jae Sung Noh
- Sang Ah Yi (ORCID: https://orcid.org/0000-0002-7048-0252)
- Jae Kyun Jeong
- Hyewon Jung (ORCID: https://orcid.org/0009-0002-9854-8076)
- Ki Hong Nam
- Jaecheol Lee (ORCID: https://orcid.org/0000-0002-2070-7463)
- Min Gyu Lee (ORCID: https://orcid.org/0000-0002-4899-6463)
- Linfan Xiao
- Jeung-Whan Han
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of Macau (MO)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.034
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00