MON-748 Vitamin D Status Upon Hospital Admission to the Internal Medicine Department and Its Relationship With Mortality

Abstract Disclosure: J. Smaha: None. J. Hrtánková: None. M. Kužma: None. P. Jackuliak: None. J. Payer: None. Background: Prehospital vitamin D status has garnered significant attention for its potential impact on hospital outcomes. However, the relationship is not universally consistent. Some studies report no significant association between prehospital vitamin D levels and hospital outcomes, arguing that confounding factors such as comorbidities or age may overshadow the direct influence of vitamin D.Material and Methods: The data of patients hospitalized at the Department of Internal Medicine of University Hospital in Bratislava from January 2018 to December 2023, such as name, surname, age, gender, serum levels of 25(OH)D, year, month and length of hospitalization, outcome of hospitalization were collected. Serum 25(OH)D concentrations (ng/mL) were obtained upon admission. All patients in the study were assessed using the same vitamin D detection method, and there was no change in the 25(OH)D measurement method during the observed period. Results: From the whole cohort, 5725 (83%) of patients were discharged, and 1163 (17%) died in the hospital. The mean 25(OH)D concentration among discharged patients was significantly higher in comparison to deceased patients (18.59 ± 11.12 ng/mL vs. 15.39 ± 11.45 ng/mL, p<0.001). Both discharged men and women had higher concentrations of 25(OH)D compared to deceased counterparts (18.60 ± 10.91 ng/mL vs. 15.67 ± 11.27 ng/mL, and 18.61 ± 11.31 ng/mL vs. 15.10 ± 11.66 ng/mL, respectively, both p<0.001). In discharged older patients (≥ 65 years), the mean 25(OH)D concentration on admission was 18.98 ± 11.32 ng/mL compared to 15.86 ± 11.55 ng/mL in deceased patients (p<0.001), and in younger patients (<65 years), the mean serum 25(OH)D concentration in discharged patients was 17.81 ± 10.67 ng/mL compared to 12.90 ± 10.81 ng/mL in deceased patients (p<0.001). There was no significant relationship between serum levels of 25(OH)D and the age of the patients (Spearman's rho=0.01, p=0.37). There was a significant inverse relationship between serum levels of 25(OH)D upon admission, and the length of the hospital stay both in men (Spearman's rho = -0.109, p<0.001) and women (Spearman's rho = -0.092, p<0.001). Deceased patients had more often chronic heart failure (p=0.01), chronic kidney disease (p=0.01), chronic pulmonary disease (p=0.03), and coronary artery disease, malignancy, > 4 comorbidities, age > 65 years (all p<0.001). In a logistic regression analysis, only serum 25(OH)D levels, age > 65 years, and malignancy were significantly associated with in-hospital death. Conclusion: Identifying vitamin D deficiency at admission provides a potential biomarker for risk stratification and could guide early interventions to improve outcomes. Future directions should focus on large-scale, randomized controlled trials to determine the efficacy of preemptive or rapid correction of vitamin D deficiency in hospitalized patients. Presentation: Monday, July 14, 2025