SUN-510 Unequal Rise: Examining Racial Variations in Malignant Pheochromocytoma Incidence

Abstract Disclosure: H.K. Ghumman: None. J. Kenmoe: None. S. Keritum: None. A. Shrestha: None. Background: Malignant pheochromocytomas are rare neuroendocrine tumors with limited data on racial disparities in their incidence. This study explores the incidence trends of malignant pheochromocytomas by race in the UnitedStates using SEER data from 2000 to 2021. Methods: A retrospective analysis of malignant pheochromocytoma cases was conducted using SEER*Stat software. Incidence rates were calculated per 100,000 person-years for racial groups: non-Hispanic White(NHW), non-HispanicBlack (NHB),non-HispanicAmericanIndian/Alaska Native, non-HispanicAsian/PacificIslander, and Hispanic of all races. Temporal trends were analyzed using Join point regression to identify significant changes. Results: The incidence of malignant pheochromocytomas was highest in NHB, followed by NHW, and Hispanics of all races. NHB and NHW exhibited a sharp and statistically significant rise in incidence from 2019 to 2021. Hispanics experienced a more gradual increase beginning around 2016, though the slope was less pronounced than the rise observed inNHB and NHW. Insufficient data were available to characterize trends for non-Hispanic Asian and AmericanIndian/Alaska Native populations using Join point regression. Conclusions: Racial disparities exist in the incidence of malignant pheochromocytomas, withNHB having the highest rates. A significant rise in incidence was observed among NHB and NHW starting in 2019, while Hispanics exhibited a more gradual increase. These findings underscore the need for further investigation into racial and temporal factors influencing incidence trends and the potential role of disparities in healthcare access or diagnostic practices. Figure1: Incidenceof MalignantPheochromocytomabyRace Presentation: Sunday, July 13, 2025