SUN-582 Rising Mortality Trends in Liver Cancer and Diabetes Mellitus: A Two-Decade Epidemiological Analysis (1999-2020)

Abstract Disclosure: F. Ahmed: None. S. Eltawansy: None. M. Bakr: None. M. Hossain: None. A. Bhat: None. R. Haider: None. R. Khunkhun: None. N. Gohar: None. T. Mirza: None. S. Murtaza Ishaq: None. A. Fayyaz: None. A. Ullah: None. O.M. Kamel: None. Introduction: A strong epidemiological relationship between diabetes mellitus (DM) and liver cancer (LC) has been established, with both conditions significantly contributing to mortality in the United States. This study explores disparities in mortality trends for DM-associated liver cancer, analyzing variations to inform targeted public health policies and preventive strategies. Methods: Mortality data from the CDC WONDER database was extracted using ICD-10 codes for liver cancer and diabetes mellitus among adults aged 25 years and older. Age-adjusted mortality rates (AAMRs) per million were calculated and stratified by gender, age groups, and racial demographics, focusing on non-Hispanic (NH) White Americans. Joinpoint regression analysis was performed to calculate the average annual percentage change (AAPC) with 95% confidence intervals (CI) and statistical significance set at p < 0.05. Results: From 1999 to 2020, DM and LC were responsible for 34,039 deaths among U.S. adults aged 25 years and older. The average AAMR over the two decades was 7.03, with the lowest AAMR recorded in 1999 at 4.75 (95% CI: 4.43-5.07) and the highest in 2020 at 9.92 (95% CI: 9.55-10.30). Analysis indicated a significant upward trend, with an AAPC of 3.18% (95% CI: 2.89-3.55, p < 0.0001). Gender-based analysis revealed that males had a significantly higher AAMR (10.82) than females (3.87). Both genders exhibited a rising trend, with an AAPC of 3.18% (95% CI: 2.90-3.55, p < 0.000001) for females and 3.30% (95% CI: 3.09-3.57, p < 0.000001) for males. Racial disparities were evident, with NH White Americans having the lowest AAMR in 2001 at 3.91 (95% CI: 3.59-4.22) and the highest in 2020 at 8.57 (95% CI: 8.16-8.97). Joinpoint analysis demonstrated a significant upward trend in the NH White population, with an AAPC of 3.64% (95% CI: 3.18-3.96, p < 0.0001). Age-specific disparities were striking, with a substantially higher AAMR in adults aged 65 years and older (28.86) compared to those aged 25-64 years (2.21). Conclusion: The escalating mortality trends for liver cancer and diabetes mellitus in the U.S. underscore an urgent public health concern. Older non-Hispanic White males exhibit the highest mortality burden, necessitating targeted interventions such as routine screening, early detection programs, and improved management strategies. Policymakers should prioritize preventive measures, particularly among high-risk groups, to mitigate the growing burden of DM-associated liver cancer. Presentation: Sunday, July 13, 2025