MON-492 Association of Epidemiological and Risk Factors with Adrenocortical Carcinoma in Adults in the United States

Abstract Disclosure: B. Chahla: None. R. Bassett: None. M. Hassan: None. M.A. Habra: None. J. Varghese: None. Background: Adrenocortical carcinoma (ACC) is a rare malignancy with limited data about its association with lifestyle, diet, or environmental risk factors. Previous reports suggest an association between oral contraceptive use and smoking with ACC but this has not been validated. Objective: To assess the association of wide range of potential environmental and personal risk factors with ACC among US adults in a hospital-based case-control study. Methods: We conducted a detailed survey of patients with confirmed ACC at The University of Texas MD Anderson Cancer Center from 2018 to 2020 and compared it with controls, who were cancer-free. Written informed consent was obtained from all participants and data was collected using a self-administered questionnaire about demographic characteristics, past medical history, risk factors for cancer and family history of cancer. Wilcoxon rank-sum tests were used to compare the distribution of continuous variables between case and control groups, and Fisher’s exact tests were used to compare the distribution of categorical variables between groups. All statistical analyses were performed using R version 4.3.1. Results: We analyzed data from 38 ACC cases (23 female [61%]) with a median age of 57 years (range, 30-81 years) and 72 controls (42 female [58%]) with a median age of 54 years (range, 24-75 years). Most of our study participants were White/Anglo-Caucasians (26 cases [68%] and 50 controls [71.4%]). There was no statistically significant difference between cases and controls in median BMIs (median BMI of 27 [range 19-54] for cases and 26 [range 18-43] for controls). There was no significant difference in other risk factors including living in industrialized areas, exposure to chemicals and substances such as asbestos and arsenic among many others as well as exposure to radiation, a prior history of cancer diagnosis, smoking and alcohol consumption, birth control use, family history of a cancer and degree of physical activity. Having a past medical history of cancer diagnosis before the current diagnosis of ACC was the only variable that was significantly different between the groups. These included one reported case of Wilms' tumor, two cases of breast cancer, and one case of basal cell carcinoma of the skin. None of the controls had a previous diagnosis of cancer. None of the other factors were significantly different between cases and controls. Conclusion: Our survey study could not find a clear association between ACC and several epidemiological risk factors and could not detect any significant risk factors for ACC except than a personal history of another malignancy. Studies including a larger number of cases and controls are needed to further corroborate our findings. Presentation: Monday, July 14, 2025