MON-723 Effect of Maternal and Paternal Health Status During Pregnancy and Early Feeding in Adolescent BMI and Abdominal Circumference: A Long-term Follow-up Cohort

Abstract Disclosure: M. Romero Ibarguengoitia: None. A. Abrego-Sánchez: None. A. Ramirez Cazares: None. D. Gutierrez González: None. A. Sánchez García: None. I. Fernández Chau: None. A. González Cantu: None. Few studies evaluate the impact of both paternal and maternal health status during pregnancy, as well as birth weight and early feeding, as indicators of obesity in adolescents. This study aims to provide insights into the role these factors through the long-term follow-up of a cohort of adolescents (10-12 years old) who received yearly medical check-ups since the pregestational stages. Information related to paternal and maternal history during pregnancy, birth weight, and early feeding was obtained from medical records. Additionally, indicators of the adolescents’ health such as body mass index (BMI), abdominal circumference, metabolic syndrome severity score (MSSS) percentile, blood pressure (BP), lipids, creatinine, uric acid, and glucose were collected. We evaluated a total of 134 adolescents, 74 (55.2%) males, with a median (IQR) age of 11 (1) years. A total of 52 subjects were overweight or obese. When comparing between normal weight vs. overweight/obesity groups, the latter had higher systolic (SBP) and diastolic (DBP) blood pressure [SBP 100(10) mmHg vs. 100(13) mmHg, p=0.002)], (DBP 60(5) vs 60(10), p=0.016)]. Other parameters that were higher in overweight or obese were creatinine (0.49(0.07) vs 0.53(0.1) mg/dl, p=0.002), uric acid (3.8(0.9) vs 4.7(1.1) mg/dl, p<0.001), and MSSS percentile (35.9(23) vs 58.5(24) %, p<0.001). Multiple regression models were performed in which the independent variable was the adolescents’ BMI percentile and abdominal circumference. In the first model, predictors for BMI percentile were paternal type 2 diabetes mellitus (ß= 0.161, p=0.003) and adolescent birth weight (ß 0.153, p=0.005), R2 of 0.649. Predictors for abdominal circumference were exclusive breastfeeding time (ß= -0.116, p=0.040) and maternal obesity (ß= 0.150, p=0.007), with an R2 of 0.614. In conclusion, this long-term follow-up study demonstrates the impact of paternal diabetes, maternal obesity, and duration of exclusive breastfeeding as predictors of BMI and abdominal circumference percentiles in their offspring during the adolescent years, with their ensuing implications for metabolic function. Presentation: Monday, July 14, 2025