SUN-380 Where Endocrine Disorders and Mental Health Converge: A 25-Year Analysis of Mortality Trends in Thyroid and Mental Health Conditions in the United States

Abstract Disclosure: A. Ahmed: None. M. Ali: None. H. Ahmad: None. S. Joshi: None. S. abid: None. F. Ahmed: None. R. Patel: None. S. Eltawansy: None. Background: Thyroid disorders (TD) and mental health (MH) conditions significantly impact global health, often influencing each other in complex ways. Recent studies suggest thyroid dysfunction can exacerbate MH disorders, while psychological conditions may disrupt endocrine function. However, trends in their combined effect on mortality remain understudied. This study aims to analyze 25-year mortality trends in thyroid and mental health disorders in the United States. Methods: Using CDC Multiple Cause of Death data (1999-2023), we analyzed mortality trends for TDs and MH among U.S. adults 25+. Age-adjusted mortality rates (AAMRs) per million were calculated, and Joinpoint regression was employed to assess annual percentage change (APC), average annual percentage change (AAPC), and p-value. Results: Over a quarter-century, TDs and MH-related conditions were responsible for 196,319 deaths. From 1999 to 2023, the overall AAMR rose from 16.63 to a striking 43.99 (AAPC: 3.97, 95% CI: 2.60, 5.34). Females experienced nearly double the AAMR compared to males (41.34 vs 22.44). However, male mortality exhibited a steeper upward trend (AAPC: 4.76, 95% CI: 3.37, 6.01) than females (AAPC: 3.84, 95% CI: 3.32, 4.36). The most rapid increases occurred from 1999 to 2001, with males experiencing a pronounced rise (APC: 22.38), while women also saw the highest mortality burden during the same period (APC: 21.98). The highest AAMR was observed in Whites (37.91), followed by American Indians (36.96) and Blacks (20.92). Notably, the steepest rise in mortality was observed in Hispanics or Latinos (AAPC: 5.73, 95% CI: 3.55, 8.94), followed by Whites (AAPC: 4.11, 95% CI: 3.58, 4.64). Geographically, the Midwest had the highest AAMR (40.37), followed by the Northeast (33.38). However, the South exhibited the most rapid increase in mortality (AAPC: 4.59, 95% CI: 4.21, 5.23). Among states, Wyoming experienced the highest mortality burden (AAMR: 187.24), while Utah had the lowest (AAMR: 30.9). Rural areas consistently demonstrated higher AAMR (17.77 to 69.08) compared to urban areas (16.39 to 44.14). Furthermore, rural areas experienced a faster rise in mortality (AAPC: 6.07, 95% CI: 5.12, 7.31) relative to urban areas (AAPC: 4.35, 95% CI: 3.76, 5.06). The period from 1999 to 2001 proved particularly disastrous for both rural (APC: 31.79) and urban areas (APC: 20.27). Individuals under 65 years (AAPC: 6.81) bore a significantly higher burden than those over 65 years (AAPC: 3.68). Conclusion: Our analysis reveals a stark rise in mortality from TDs and MH conditions. Notably, rural areas, younger populations, males and Hispanics/Latinos exhibited the fastest increases in mortality, underscoring urgent disparities in healthcare access and outcomes. Presentation: Sunday, July 13, 2025