SUN-119 Thyrotropin values do not affect metabolic and hormonal profile in euthyroid women with PCOS

Abstract Disclosure: S. Livadas: None. N. Angelopoulos: None. R. Paparodis: None. J. Bjekic Macut: None. R. Robeva: None. J. Kuliczkowska-Płaksej: None. A. Vryonidou: None. G. Mastorakos: None. D. Μacut: None. Introduction: Thyroid function is essential for human metabolism and abnormal thyroid function tests (TFTs) have been associated with unfavourable metabolic and hormonal profile in women with PCOS. However, it is not known if slight variations of TSH values affect these parameters in euthyroid women with PCOS. On clinical grounds if a significant association is revealed one may suggest thyroxine treatment in this population even with TFTs between normal values. Subjects and Methods: Cross sectional data of 1762 European women of Caucasian origin (age: 24.57±5.54 years, BMI: 26.34±6.88 kg/m2) diagnosed with PCOS (Rotterdam criteria) were analysed. All subjects, had both normal TSH values (0.4-4.7 IU/ml) and either T4 or FT4 values. None of the subjects was on treatment with Thyroxine. Anthropometric parameters (age, BMI, WHR, FG Score), metabolic indices (glucose, lipids, liver function, HOMA-IR) and hormonal (gonadotropins, testosterone, SHBG, DHEAS, D4, FAI, estradiol, insulin) values were evaluated. Data were stratified initially based on TSH values (higher or lower of 2.5IU/ml) and Group A (TSH < 2.5 IU/ml) and Group B (TSH < 2.5 IU/ml) were formed. In addition, data were stratified according to TSH quartiles (Q1, TSH 0.4-1.5, Q2 1.5-2.5, Q3, TSH 2.5-3.5, Q4, TSH> 3.5-4.7 IU/ml). Results: The comparison between Groups A and B reached significant difference (p<0.05) in TSH values (1.49±0.58 vs. 3.98±0.56IU/ml) as expected. However, except SHBG (40.78±19.55 vs.37.96±19.64 nmol/L) and DHEAS values (3.03±1.35 vs. 2.84±1.32 nmol/L), no difference was observed in any other parameter evaluated (Table 1). When data were analysed based on TSH quartiles, despite TSH values, statistical significance was shown in subgroups regarding LH, FSH, SHBG and DHEAS values. Conclusions: Our findings originated from a large European cohort suggest that TSH values in euthyroid women with PCOS are not significantly associated with any metabolic and hormonal parameter except SHBG and DHEAS. Therefore, we advocate against thyroxine administration in women with PCOS and TSH values between normal range. Presentation: Sunday, July 13, 2025