SUN-601 Trends And Disparities in COPD and Diabetes Mellitus-Related Mortality in The United States, 1999-2020: A CDC Wonder Analysis

Abstract Disclosure: H. Batool: None. R. Noor: None. S. Cheema: None. R. Ali: None. S. Yasmin: None. S. iftikhar: None. A. Dixit: None. A.R. Syed: None. S. Sahu: None. Introduction:Globally, chronic obstructive pulmonary disease (COPD) ranks as the third leading cause ofmortality. The complicated course of diabetes mellitus (DM) may be attributed to COPD, whichis acknowledged as a substantial risk factor. This study aims to analyze the trends and disparitiesof COPD and DM among adults aged 25 and above in the United States from 1999-2020. Methods: Using the ICD 10 codes J40, J41.0, J41.1, J41.8, J42, J43.0, J43.1, J43.2, J43.8, J43.9, J44.0,J44.1, J44.8, J44.9 (COPD) AND E10-E14 (Diabetes mellitus), mortality metrics were extractedfrom death certificates recorded with the CDC WONDER database between 1999 and 2020. Theanalysis incorporated the annual percent change (APC) and average annual percent change(AAPC) with 95% confidence intervals and the age-adjusted mortality rates (AAMR) per100,000 people. When parallelism was evaluated using the Joinpoint Regression Program, a p-value of less than 0.05 was deemed significant for unparalleled. Likewise, demographic trendswere assessed for age, gender, race, and urban/rural classification. Results: Throughout the study period, 668204 mortalities were reported owing to COPD and diabetes.From 1999 to 2008, there was a steep rise in AAMR from 10.79 to 14.32 (APC: 3.07), followedby a constant slope from 14.32 in 2008 to 14.74 in 2018 (APC: 0.057), and ultimately, a sharprising curve was obtained from 14.74 in 2018 to 18.91 in 2020 (APC: 13.06) (AAPC: 2.52; 95%CI, 2.10-2.96, p< 0.000001). Males had a higher AAMR (18.01) than females (11.11), with amore abrupt rise in AAMR from 2018 to 2020 (APC: 13.15). Notable disparities were observedregarding urbanization and race, non-metropolitan areas and American Indian or Alaska Nativeshad the highest AAMR. The Midwest census region had the highest AAMR (15.83), followed bySouth (14.86), West (12.98), and lastly Northeast (11.15). The 85+ age group reported thehighest crude death rate (102.35) and the state of West Virginia (28.25) had the highest AAMR.Lastly, the highest percentage of deaths were reported in the Inpatient medical facilities. Conclusion: In the US, the fatality rate from diabetes and COPD has been rising abruptly. This upsurge isalarming and warrants swift, concentrated remedies, particularly in the state of West Virginiaand the Midwest census region. The stark differences in death rates by geography anddemographics highlight the pressing need for targeted research and resource distribution. Highinpatient mortality rates and unequal access to treatment, particularly in impoverished areas, areclear indicators of the healthcare burden. To address these issues and lessen the continuousburden on healthcare systems, improved public health initiatives, fair resource distribution, andpreventative measures are needed. Presentation: Sunday, July 13, 2025