SAT-204 Associations Between Children and Parental Well-Being in Growth Hormone Deficiency

Abstract Disclosure: A. De Arriba Munoz: None. A. García Durán: None. P. Sanz Aznar: None. S. Quer Palomas: None. I. Bilionis: None. A. Xifra-Porxas: None. J. Nuñez: None. R.C. Berrios: None. L. Fernández Luque: This investigator-sponsored study has been funded by Merck Healthcare KGaA, Darmstadt Germany, which is a type of sponsored independent research. As independent study, the funder does not participate, Adhera Health owns the solution used in the study (This applies to all authors from Adhera Health). Introduction: Growth hormone deficiency (GHD) affects both children and their caregivers, posing emotional, physical, and social challenges. This study examines the association between caregiver and child well-being. Methods: Fifty caregivers (mean age 42.1y; 31% male) of children with GHD (mean age 8.4y; 49% male) completed a 3-month digital program aimed at supporting their well-being.[IB1] In this study, we focused on the psychometric questionnaires completed by the caregivers. Associations between caregiver and child well-being were analyzed using Spearman’s correlation. Results: Children with better overall well-being (measured via KIDSCREEN-10) had caregivers with improved overall well-being (measured via PANAS, MHC-SF, GSE and DASS21). Specifically, items addressing the emotional and physical state of the children were among those strongly associated with caregiver well-being. For instance, children feeling sadder had parents feeling more stress (r=0.476, p<0.001) and anxiety (r=-0.471, p<0.001), while caregivers’ negative affect was higher when they felt their children were being treated unfairly (r=-0.583, p<0.001). Furthermore, only two QoLISSY child subscales were significantly associated with caregiver well-being: the child’s coping with the disease (Coping subscale) and their feelings about the treatment (Treatment subscale). For example, children coping poorly with the disease had parents who exhibited depressive symptoms (r=-0.486, p<0.001). Moreover, lower scores in the QoLISSY parent subscale “Effects on parents”, indicating parents who struggle with the management of the disease, were significantly associated with children feeling sadder (r=-0.340, p=0.009) and overall with poorer health (r=0.337, p=0.010). Finally, higher scores on the QoLISSY parent subscale “Future” were significantly associated with higher scores in the QoLISSY child subscale about their emotional well-being (r=0.509, p<0.001), indicating that less concern about the future was tied to better child emotional well-being. Discussion: This study underscores the strong relationship between child and caregiver well-being in families managing GHD. Children’s emotional and physical challenges are closely linked with caregiver mental health, as well as children’s coping and treatment experiences. These findings emphasize the need for family-centered interventions to support both children and caregivers, improving outcomes for families managing GHD. Presentation: Saturday, July 12, 2025